The increasing complexities of prostate cancer disease progression necessitates more stable and less toxic therapeutic strategies. The current study demonstrated for the first time, the survivin targeted anti-cancer therapeutic activity of the bio-molecular drugs such as SurR9-C84A and bovine lactoferrin in inducing prostate cancer specific apoptosis. Moreover, improved therapeutic efficacy was conferred to these bio-molecules either by their encapsulation in stem cell targeted bio-compatible nanoparticles, or by the synthesis of protein-cytotoxic drug conjugates. This study also highlighted the role played by miRNAs in the regulation of iron metabolism and apoptosis, mediated by the selective activation of p53 and PTEN pathways.
Field of Research
111201 Cancer Cell Biology 111204 Cancer Therapy (excl Chemotherapy and Radiation Therapy) 100709 Nanomedicine
Socio Economic Objective
920102 Cancer and Related Disorders
Description of original
ix, 540 pages : illustrations, tables, graphs, some coloured
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