Molecular regulation of survivin targeted nano-therapy in advanced prostate cancer

Shankara Narayanan, Jayanth Surya Narayanan 2015, Molecular regulation of survivin targeted nano-therapy in advanced prostate cancer, PhD thesis, School of Medicine, Deakin Univeristy.

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Title Molecular regulation of survivin targeted nano-therapy in advanced prostate cancer
Author Shankara Narayanan, Jayanth Surya Narayanan
Institution Deakin Univeristy
School School of Medicine
Faculty Faculty of Health
Degree type Research doctorate
Degree name PhD
Thesis advisor Kanwar (nee Kaur), Rupinder
Kanwar JagatORCID iD for Kanwar Jagat
Date submitted 2015-03
Keyword(s) prostate cancer
Summary  The increasing complexities of prostate cancer disease progression necessitates more stable and less toxic therapeutic strategies. The current study demonstrated for the first time, the survivin targeted anti-cancer therapeutic activity of the bio-molecular drugs such as SurR9-C84A and bovine lactoferrin in inducing prostate cancer specific apoptosis. Moreover, improved therapeutic efficacy was conferred to these bio-molecules either by their encapsulation in stem cell targeted bio-compatible nanoparticles, or by the synthesis of protein-cytotoxic drug conjugates. This study also highlighted the role played by miRNAs in the regulation of iron metabolism and apoptosis, mediated by the selective activation of p53 and PTEN pathways.
Language eng
Field of Research 111201 Cancer Cell Biology
111204 Cancer Therapy (excl Chemotherapy and Radiation Therapy)
100709 Nanomedicine
Socio Economic Objective 920102 Cancer and Related Disorders
Description of original ix, 540 pages : illustrations, tables, graphs, some coloured
Dewey Decimal Classification 616.99463
Restricted until 2023-09-01
Copyright notice ┬ęThe Author. All Rights Reserved.
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Document type: Thesis
Collection: Higher degree theses (citation only)
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