Cost-effectiveness of a bivalent human papillomavirus vaccination program in Japan

Connelly, Luke B. and Le, Ha N. D. 2015, Cost-effectiveness of a bivalent human papillomavirus vaccination program in Japan, Sexual health, vol. 12, no. 6, pp. 520-531, doi: 10.1071/SH14241.

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Title Cost-effectiveness of a bivalent human papillomavirus vaccination program in Japan
Author(s) Connelly, Luke B.
Le, Ha N. D.ORCID iD for Le, Ha N. D.
Journal name Sexual health
Volume number 12
Issue number 6
Start page 520
End page 531
Total pages 12
Publisher CSIRO Publishing
Place of publication Melbourne, Vic.
Publication date 2015
ISSN 1448-5028
Keyword(s) Cervical cancer
Summary Background Human papillomavirus (HPV) vaccines and their widespread adoption have the potential to relieve a large part of the burden of cervical cancer morbidity and mortality, particularly in countries that have low screening rates or, like Japan, lack a cohesive universal screening program. An economic evaluation was conducted to assess the cost-effectiveness of introducing a bivalent HPV vaccination program in Japan from a healthcare perspective. METHODS: A Markov model of the natural history of HPV infection that incorporates both vaccination and screening was developed for Japan. The modelled intervention, a bivalent HPV vaccine with a 100% lifetime vaccine efficacy and 80% vaccine coverage, given to a cohort of 12-year-old Japanese girls in conjunction with the current screening program, was compared with screening alone in terms of costs and effectiveness. A discount rate of 5% was applied to both costs and utilities where relevant. RESULTS: Vaccination alongside screening compared with screening alone is associated with an incremental cost-effectiveness ratio (ICER) of US$20315 per quality-adjusted-life-year gained if 80% coverage is assumed. The ICER at 5% coverage with the vaccine plus screening, compared with screening alone, is US$1158. CONCLUSION: The cost-effectiveness results suggest that the addition of a HPV vaccination program to Japan's cervical cancer screening program is highly likely to prove a cost-effective way to reduce the burden of cervical cancer, precancerous lesions and HPV16/18-related diseases.
Language eng
DOI 10.1071/SH14241
Field of Research 111799 Public Health and Health Services not elsewhere classified
11 Medical And Health Sciences
16 Studies In Human Society
Socio Economic Objective 920599 Specific Population Health (excl. Indigenous Health) not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, CSIRO Publishing
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