This research was focused upon members of the ADAMTS family of 'proteinases', proteins that have enzymatic activity. Their dysregulation can cause developmental defects and disease. This thesis describes the expression and regulation of ADAMTS15, as well as new developmental functions and inhibition of ADAMTS5 in arthritis.
Field of Research
060803 Animal Developmental and Reproductive Biology 110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics) 110322 Rheumatology and Arthritis
Socio Economic Objective
920116 Skeletal System and Disorders (incl. Arthritis)
Description of original
xiii, 165 pages : illustrations, some coloured, tables, graphs
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