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Youth Depression Alleviation-Augmentation with an anti-inflammatory agent (YoDA-A): protocol and rationale for a placebo-controlled randomized trial of rosuvastatin and aspirin

Quinn, Amelia L., Dean, Olivia M., Davey, Christopher G., Kerr, Melissa, Harrigan, Susy M., Cotton, Sue M., Chanen, Andrew M., Dodd, Seetal, Ratheesh, Aswin, Amminger, G. Paul, Phelan, Mark, Williams, Amber, Mackinnon, Andrew, Giorlando, Francesco, Baird, Shelley, Rice, Simon, O'Shea, Melissa, Schäfer, Miriam R., Mullen, Edward, Hetrick, Sarah, McGorry, Patrick and Berk, Michael 2015, Youth Depression Alleviation-Augmentation with an anti-inflammatory agent (YoDA-A): protocol and rationale for a placebo-controlled randomized trial of rosuvastatin and aspirin, Early intervention in psychiatry, Early view, pp. 1-10, doi: 10.1111/eip.12280.

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Title Youth Depression Alleviation-Augmentation with an anti-inflammatory agent (YoDA-A): protocol and rationale for a placebo-controlled randomized trial of rosuvastatin and aspirin
Author(s) Quinn, Amelia L.
Dean, Olivia M.ORCID iD for Dean, Olivia M. orcid.org/0000-0002-2776-3935
Davey, Christopher G.
Kerr, Melissa
Harrigan, Susy M.
Cotton, Sue M.
Chanen, Andrew M.
Dodd, SeetalORCID iD for Dodd, Seetal orcid.org/0000-0002-7918-4636
Ratheesh, Aswin
Amminger, G. Paul
Phelan, Mark
Williams, Amber
Mackinnon, Andrew
Giorlando, Francesco
Baird, Shelley
Rice, Simon
O'Shea, Melissa
Schäfer, Miriam R.
Mullen, Edward
Hetrick, Sarah
McGorry, Patrick
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Early intervention in psychiatry
Season Early view
Start page 1
End page 10
Total pages 10
Publisher Wiley
Place of publication London, Eng.
Publication date 2015-11-05
ISSN 1751-7885
1751-7893
Keyword(s) aspirin
depression
inflammation
rosuvastatin
youth
Summary AIM: There is growing support for the role of inflammation and oxidative stress in the pathophysiology of major depressive disorder (MDD). This has led to the development of novel strategies targeting inflammation in the treatment of depression. Rosuvastatin and aspirin have well-documented, anti-inflammatory and antioxidant properties. The aim of the Youth Depression Alleviation: Augmentation with an anti-inflammatory agent (YoDA-A) study is to determine whether individuals receiving adjunctive anti-inflammatory agents, aspirin and rosuvastatin experience a reduction in the severity of MDD compared with individuals receiving placebo. METHODS: YoDA-A is a 12-week triple-blind, randomized controlled trial funded by the National Health and Medical Research Council, Australia. Participants aged 15-25, with moderate-to-severe MDD, are allocated to receive either 10 mg/day rosuvastatin, 100 mg/day aspirin, or placebo, in addition to treatment as usual. Participants are assessed at baseline and at weeks 4, 8, 12 and 26. The primary outcome is change in the Montgomery-Åsberg Depression Rating Scale (MADRS) from baseline to week 12. RESULTS: The study is planned to be completed in 2017. At date of publication, 85 participants have been recruited. CONCLUSION: Timely and targeted intervention for youth MDD is crucial. Given the paucity of new agents to treat youth MDD, adjunctive trials are not only pragmatic and 'real-world', but additionally aim to target shortfalls in conventional medications. This study has the potential to first provide two new adjunctive treatment options for youth MDD; aspirin and rosuvastatin. Second, this study will serve as proof of principle of the role of inflammation in MDD.
Language eng
DOI 10.1111/eip.12280
Field of Research 091103 Ocean Engineering
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30079498

Document type: Journal Article
Collection: School of Medicine
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Created: Thu, 12 Nov 2015, 15:04:56 EST

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