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Chronic traumatic encephalopathy: historical origins and current perspective

Montenigro, Philip H., Corp, Daniel T., Stein, Thor D., Cantu, Robert C. and Stern, Robert A. 2015, Chronic traumatic encephalopathy: historical origins and current perspective, Annual review of clinical psychology, vol. 11, pp. 309-330, doi: 10.1146/annurev-clinpsy-032814-112814.

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Title Chronic traumatic encephalopathy: historical origins and current perspective
Author(s) Montenigro, Philip H.
Corp, Daniel T.
Stein, Thor D.
Cantu, Robert C.
Stern, Robert A.
Journal name Annual review of clinical psychology
Volume number 11
Start page 309
End page 330
Total pages 22
Publisher Annual Reviews
Place of publication Palo Alto, Calif.
Publication date 2015-03
ISSN 1548-5951
Keyword(s) Chronic traumatic encephalopathy
Concussion
Football
History
Neurodegenerative disorders
Traumatic brain injury
Social Sciences
Psychology, Clinical
Psychology
PROFESSIONAL FOOTBALL PLAYERS
REPETITIVE BRAIN TRAUMA
RESEARCH DIAGNOSTIC-CRITERIA
APOLIPOPROTEIN-E-GENOTYPE
LONG-TERM CONSEQUENCES
WHITE-MATTER INTEGRITY
MILD HEAD-INJURY
ALZHEIMERS-DISEASE
HIGH-SCHOOL
LEAGUE PLAYERS
Summary Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that is most often identified in postmortem autopsies of individuals exposed to repetitive head impacts, such as boxers and football players. The neuropathology of CTE is characterized by the accumulation of hyperphosphorylated tau protein in a pattern that is unique from that of other neurodegenerative diseases, including Alzheimer's disease. The clinical features of CTE are often progressive, leading to dramatic changes in mood, behavior, and cognition, frequently resulting in debilitating dementia. In some cases, motor features, including parkinsonism, can also be present. In this review, the historical origins of CTE are revealed and an overview of the current state of knowledge of CTE is provided, including the neuropathology, clinical features, proposed clinical and pathological diagnostic criteria, potential in vivo biomarkers, known risk factors, and treatment options.
Language eng
DOI 10.1146/annurev-clinpsy-032814-112814
Field of Research 170106 Health, Clinical and Counselling Psychology
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Annual Reviews
Persistent URL http://hdl.handle.net/10536/DRO/DU:30079501

Document type: Journal Article
Collection: School of Psychology
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Created: Thu, 12 Nov 2015, 16:08:22 EST

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