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Future directions for pharmacotherapies for treatment-resistant bipolar disorder

Dodd, Seetal, Dean, Olivia M. and Fernandes, Brisa S. 2015, Future directions for pharmacotherapies for treatment-resistant bipolar disorder, Current neuropharmacology, vol. 13, no. 5, pp. 656-662, doi: 10.2174/1570159X13666150630175841.

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Title Future directions for pharmacotherapies for treatment-resistant bipolar disorder
Author(s) Dodd, Seetal
Dean, Olivia M.
Fernandes, Brisa S.
Journal name Current neuropharmacology
Volume number 13
Issue number 5
Start page 656
End page 662
Total pages 7
Publisher Bentham Science Publishers
Place of publication Bussum, The Netherlands
Publication date 2015-09
ISSN 1875-6190
Keyword(s) Bipolar disorder
Inflammation
Nitrosative stress
Oxidative stress
Pathways
Pharmacotherapy
Receptors
Treatment targets
Summary Current pharmacological treatments for bipolar disorder (BD) are limited and efficacy has historically been discovered through serendipity. There is now scope for new drug development, focused on the underlying biology of BD that is not targeted by current therapies. The need for novel treatments is urgent when considering treatment resistant BD, where current therapies have failed. While established drugs targeting the monoamine systems continue to be worthwhile, new biological targets including inflammatory and oxidative an nitrosative pathways, apoptotic and neurotrophic pathways, mitochondrial pathways, the N-methyl-Daspartate (NMDA)-receptor complex, the purinergic system, neuropeptide system, cholinergic system and melatonin pathways are all being identified as potential anchors for the discovery of new agents. Many agents are experimental and efficacy data is limited, however further investigation may provide a new line for drug discovery, previously stalled by lack of corporate interest.
Language fre
DOI 10.2174/1570159X13666150630175841
Field of Research 111502 Clinical Pharmacology and Therapeutics
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Bentham Science Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30079513

Document type: Journal Article
Collection: School of Medicine
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Created: Fri, 13 Nov 2015, 09:59:33 EST

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