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Antidepressant medication may moderate the effect of depression duration on hippocampus volume

Rogers, Mark A., Yamasue, Hidenori and Kasai, Kiyoto 2015, Antidepressant medication may moderate the effect of depression duration on hippocampus volume, Journal of psychophysiology, vol. 30, pp. 1-8, doi: 10.1027/0269-8803/a000148.

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Title Antidepressant medication may moderate the effect of depression duration on hippocampus volume
Author(s) Rogers, Mark A.
Yamasue, Hidenori
Kasai, Kiyoto
Journal name Journal of psychophysiology
Volume number 30
Start page 1
End page 8
Total pages 8
Publisher Hogrefe
Place of publication Gottingen, Germany
Publication date 2015
ISSN 0269-8803
2151-2124
Keyword(s) major depression
hippocamp volume
antidepressant
Summary Abstract.
Hippocampus volume has been frequently, but not universally reported to be reduced in people with major depression relative to age-matched healthy controls. Among the potential reasons for this discrepancy in finding across studies is the effect of antidepressant medication. Hippocampus volume was determined by MRI (1.5 Tesla) for 10 people diagnosed with major depression for who detailed history of depression and antidepressant treatment history were known, and 10 age-matched healthy controls with no history of depression. Left, but not right, hippocampus volumes were significantly smaller in the patient group compared to the controls. Furthermore, there was a significant correlation such that left hippocampus volume was smaller with increasing lifetime duration of depression. However, this relationship was moderated by a significant correlation such that greater lifetime duration of antidepressant medication was associated with larger left hippocampus volume.
The findings support the contention that antidepressant medication may act to normalize hippocampus volume.
Language eng
DOI 10.1027/0269-8803/a000148
Field of Research 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Socio Economic Objective 920401 Behaviour and Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Hogrefe
Persistent URL http://hdl.handle.net/10536/DRO/DU:30079586

Document type: Journal Article
Collection: School of Psychology
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