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"Cancer 2015": a prospective, population-based cancer cohort-phase 1: feasibility of genomics-guided precision medicine in the clinic

Parisot, John P., Thorne, Heather, Fellowes, Andrew, Doig, Ken, Lucas, Mark, McNeil, John J., Doble, Brett, Dobrovic, Alexander, John, Thomas, James, Paul A., Lipton, Lara, Ashley, David, Hayes, Theresa, McMurrick, Paul, Richardson, Gary, Lorgelly, Paula, Fox, Stephen B. and Thomas, David M. 2015, "Cancer 2015": a prospective, population-based cancer cohort-phase 1: feasibility of genomics-guided precision medicine in the clinic, Journal of personalized medicine, vol. 5, no. 4, pp. 354-369, doi: 10.3390/jpm5040354.

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Title "Cancer 2015": a prospective, population-based cancer cohort-phase 1: feasibility of genomics-guided precision medicine in the clinic
Author(s) Parisot, John P.
Thorne, Heather
Fellowes, Andrew
Doig, Ken
Lucas, Mark
McNeil, John J.
Doble, Brett
Dobrovic, Alexander
John, Thomas
James, Paul A.
Lipton, Lara
Ashley, David
Hayes, Theresa
McMurrick, Paul
Richardson, Gary
Lorgelly, Paula
Fox, Stephen B.
Thomas, David M.
Journal name Journal of personalized medicine
Volume number 5
Issue number 4
Start page 354
End page 369
Total pages 16
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2015
ISSN 2075-4426
Keyword(s) cancer genomics cohort
health economics
next-Gen sequencing
precision medicine
Summary "Cancer 2015" is a longitudinal and prospective cohort. It is a phased study whose aim was to pilot recruiting 1000 patients during phase 1 to establish the feasibility of providing a population-based genomics cohort. Newly diagnosed adult patients with solid cancers, with residual tumour material for molecular genomics testing, were recruited into the cohort for the collection of a dataset containing clinical, molecular pathology, health resource use and outcomes data. 1685 patients have been recruited over almost 3 years from five hospitals. Thirty-two percent are aged between 61-70 years old, with a median age of 63 years. Diagnostic tumour samples were obtained for 90% of these patients for multiple parallel sequencing. Patients identified with somatic mutations of potentially "actionable" variants represented almost 10% of those tumours sequenced, while 42% of the cohort had no mutations identified. These genomic data were annotated with information such as cancer site, stage, morphology, treatment and patient outcomes and health resource use and cost. This cohort has delivered its main objective of establishing an upscalable genomics cohort within a clinical setting and in phase 2 aims to develop a protocol for how genomics testing can be used in real-time clinical decision-making, providing evidence on the value of precision medicine to clinical practice.
Language eng
DOI 10.3390/jpm5040354
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30079608

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.