Transcranial magnetic stimulation in autism spectrum disorder: challenges, promise, and roadmap for future research

Oberman, Lindsay M., Enticott, Peter G., Casanova, Manuel F., Rotenberg, Alexander, Pascual-Leone, Alvaro and McCracken, James T. 2016, Transcranial magnetic stimulation in autism spectrum disorder: challenges, promise, and roadmap for future research, Autism research, vol. 9, no. 2, pp. 184-203, doi: 10.1002/aur.1567.

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Title Transcranial magnetic stimulation in autism spectrum disorder: challenges, promise, and roadmap for future research
Author(s) Oberman, Lindsay M.
Enticott, Peter G.ORCID iD for Enticott, Peter G.
Casanova, Manuel F.
Rotenberg, Alexander
Pascual-Leone, Alvaro
McCracken, James T.
Journal name Autism research
Volume number 9
Issue number 2
Start page 184
End page 203
Total pages 20
Publisher International Society for Autism Research
Place of publication Hoboken, NJ
Publication date 2016-02
ISSN 1939-3806
Keyword(s) autism spectrum disorder
transcranial magnetic stimulation
TMS in ASD Consensus Group
Summary Autism Spectrum Disorder (ASD) is a behaviorally defined complex neurodevelopmental syndrome characterized by impairments in social communication, by the presence of restricted and repetitive behaviors, interests and activities, and by abnormalities in sensory reactivity. Transcranial magnetic stimulation (TMS) is a promising, emerging tool for the study and potential treatment of ASD. Recent studies suggest that TMS measures provide rapid and noninvasive pathophysiological ASD biomarkers. Furthermore, repetitive TMS (rTMS) may represent a novel treatment strategy for reducing some of the core and associated ASD symptoms. However, the available literature on the TMS use in ASD is preliminary, composed of studies with methodological limitations. Thus, off-label clinical rTMS use for therapeutic interventions in ASD without an investigational device exemption and outside of an IRB approved research trial is premature pending further, adequately powered and controlled trials. Leaders in this field have gathered annually for a two-day conference (prior to the 2014 and 2015 International Meeting for Autism Research, IMFAR) to share recent progress, promote collaboration across laboratories, and establish consensus on protocols. Here we review the literature in the use of TMS in ASD in the context of the unique challenges required for the study and exploration of treatment strategies in this population. We also suggest future directions for this field of investigations. While its true potential in ASD has yet to be delineated, TMS represents an innovative research tool and a novel, possibly transformative approach to the treatment of neurodevelopmental disorders. Autism Res 2015. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.
Language eng
DOI 10.1002/aur.1567
Field of Research 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
110903 Central Nervous System
110319 Psychiatry (incl Psychotherapy)
1103 Clinical Sciences
1109 Neurosciences
1701 Psychology
Socio Economic Objective 920410 Mental Health
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2015, International Society for Autism Research
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Document type: Journal Article
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School of Psychology
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