The guardians of inherited oncogenic vulnerabilities

Arnal, Audrey, Tissot, Tazzio, Ujvari, Beata, Nunney, Leonard, Solary, Eric, Laplane, Lucie, Bonhomme, François, Vittecoq, Marion, Tasiemski, Aurélie, Renaud, François, Pujol, Pascal, Roche, Benjamin and Thomas, Frédéric 2016, The guardians of inherited oncogenic vulnerabilities, Evolution, vol. 70, no. 1, pp. 1-6, doi: 10.1111/evo.12809.

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Title The guardians of inherited oncogenic vulnerabilities
Author(s) Arnal, Audrey
Tissot, Tazzio
Ujvari, BeataORCID iD for Ujvari, Beata
Nunney, Leonard
Solary, Eric
Laplane, Lucie
Bonhomme, François
Vittecoq, Marion
Tasiemski, Aurélie
Renaud, François
Pujol, Pascal
Roche, Benjamin
Thomas, Frédéric
Journal name Evolution
Volume number 70
Issue number 1
Start page 1
End page 6
Total pages 6
Publisher Wiley-Blackwell
Place of publication Hoboken, N.J.
Publication date 2016-01
ISSN 0014-3820
Keyword(s) cancer
natural defenses
purifying selection
somatic mutations
Summary Similar to seemingly maladaptive genes in general, the persistence of inherited cancer-causing mutant alleles in populations remains a challenging question for evolutionary biologists. In addition to traditional explanations such as senescence or antagonistic pleiotropy, here we put forward a new hypothesis to explain the retention of oncogenic mutations. We propose that although natural defenses evolve to prevent neoplasm formation and progression thus increasing organismal fitness, they also conceal the effects of cancer-causing mutant alleles on fitness and concomitantly protect inherited ones from purging by purifying selection. We also argue for the importance of the ecological contexts experienced by individuals and/or species. These contexts determine the locally predominant fitness-reducing risks, and hence can aid the prediction of how natural selection will influence cancer outcomes.
Language eng
DOI 10.1111/evo.12809
Field of Research 060305 Evolution of Developmental Systems
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, The Authors
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