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Vitamin B12 and cognitive impairment

Moore, Eileen M., Watters, David A.K., Ames, David and Mander, Alastair G. 2015, Vitamin B12 and cognitive impairment. In Martin, Colin R. and Preedy, Victor R. (ed), Diet and nutrition in dementia and cognitive decline, Elsevier, London, Eng., pp.637-648, doi: 10.1016/B978-0-12-407824-6.00059-8.

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Title Vitamin B12 and cognitive impairment
Author(s) Moore, Eileen M.
Watters, David A.K.
Ames, David
Mander, Alastair G.
Title of book Diet and nutrition in dementia and cognitive decline
Editor(s) Martin, Colin R.
Preedy, Victor R.
Publication date 2015
Chapter number 59
Total chapters 112
Start page 637
End page 648
Total pages 12
Publisher Elsevier
Place of Publication London, Eng.
Summary Vitamin B12 is an essential vitamin required for neurological health. The main causes of deficiency (hypoacidity of the stomach, pernicious anemia, and lack of dietary intake) are more prevalent with increasing age. This chapter discusses the epidemiological evidence that suggests an association between low vitamin B12 levels and cognitive decline. To date, short term clinical trials have only shown B12 supplementation to be effective in improving cognition in those with preexisting deficiency (<150. ρmol/L). Improving dietary B12 intake by better food selection, fortified foods, or supplements, may have a role in maintaining cognitive function in those who are at risk of developing B12 deficiency. To be effective, such intervention may need to be commenced before the onset of neuronal damage in middle age, particularly in those with a B12 level of less than 250. ρmol/L. Trials to study when and for how long to provide B12 supplementation are needed.
ISBN 9780124079397
Language eng
DOI 10.1016/B978-0-12-407824-6.00059-8
Field of Research 110399 Clinical Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category BN.1 Other book chapter, or book chapter not attributed to Deakin
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30079920

Document type: Book Chapter
Collection: School of Medicine
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