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Serum triglycerides, but not cholesterol or leptin, are decreased in suicide attempters with mood disorders

da Graça Cantarelli, Maria, Nardin, Patrícia, Buffon, Andréia, Eidt, Murilo Castilhos, Godoy, Luiz Antonio, Fernandes, Brisa S. and Gonçalves, Carlos-Alberto 2015, Serum triglycerides, but not cholesterol or leptin, are decreased in suicide attempters with mood disorders, Journal of affective disorders, vol. 172, pp. 403-409, doi: 10.1016/j.jad.2014.10.033.

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Title Serum triglycerides, but not cholesterol or leptin, are decreased in suicide attempters with mood disorders
Author(s) da Graça Cantarelli, Maria
Nardin, Patrícia
Buffon, Andréia
Eidt, Murilo Castilhos
Godoy, Luiz Antonio
Fernandes, Brisa S.ORCID iD for Fernandes, Brisa S. orcid.org/0000-0002-3797-7582
Gonçalves, Carlos-Alberto
Journal name Journal of affective disorders
Volume number 172
Start page 403
End page 409
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015
ISSN 0165-0327
Keyword(s) cholesterol
mood affective disorders
leptin
suicide
triglycerides
Summary Background
Many peripheral biomarkers, including low cholesterol and its fractions, have been examined to identify suicidal behavior. Herein, we assessed serum lipid profile and some proteins putatively associated with suicidal behavior in subjects with mood disorder (bipolar disorder or major depressive disorder) with a recent suicide attempt and with no lifetime history of suicide attempts.

Methods
Fifty subjects had presented an episode of attempted suicide during the last 15 days, and 36 subjects had no history of any suicide attempt. We measured total cholesterol, HDL, LDL and triglycerides as well as serum leptin, brain-derived neurotrophic factor (BDNF), S100B and C-reactive protein (CRP).

Results
Individuals that had attempted suicide presented decreased body mass index (BMI) and waist circumference. After adjusting for these confounders, we found that triglycerides were decreased in attempted suicide subjects. We found no differences among total cholesterol, LDL, and HDL or leptin, S100B, CRP and BDNF.

Limitations
This is a cross-sectional study, and we cannot therefore assess whether a decrease in triglycerides caused a mood episode with suicidal ideation that led to a suicide attempt or if the presence of a mood episode originated a loss of appetite and consequent loss of weight, therefore decreasing triglyceride levels.

Conclusions
These results do not support the hypothesis that lower levels of cholesterol are associated with suicidal behavior in a mood disorder sample. However, our data support the idea that adiposity is differentiated in these patients (reduced BMI, waist circumference and serum triglycerides), which could lead to an altered communication between the adipose tissue and brain.
Language eng
DOI 10.1016/j.jad.2014.10.033
Field of Research 11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Grant ID None.
Copyright notice ©2014, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution Non-Commercial No-Derivatives licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30079981

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.