A novel graphene nanodots inlaid porous gold electrode for electrochemically controlled drug release

Wang, Jianmei, Yang, Peng, Cao, Mengmei, Kong, Na, Yang, Wenrong, Sun, Shu, Meng, You and Liu, Jingquan 2016, A novel graphene nanodots inlaid porous gold electrode for electrochemically controlled drug release, Talanta, vol. 147, pp. 184-192, doi: 10.1016/j.talanta.2015.09.020.

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Title A novel graphene nanodots inlaid porous gold electrode for electrochemically controlled drug release
Author(s) Wang, Jianmei
Yang, Peng
Cao, Mengmei
Kong, Na
Yang, WenrongORCID iD for Yang, Wenrong orcid.org/0000-0001-8815-1951
Sun, Shu
Meng, You
Liu, Jingquan
Journal name Talanta
Volume number 147
Start page 184
End page 192
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-01-15
ISSN 1873-3573
Keyword(s) graphene nanodots
porous gold
ion beam sputtering deposition
electrochemistry
drug release
electrostatic repulsion process
Science & Technology
Physical Sciences
Chemistry, Analytical
Chemistry
ANTICANCER DRUG
HYBRID NANOPARTICLES
SILICA NANOPARTICLES
DELIVERY
OXIDE
COMPOSITES
SURFACES
THERAPEUTICS
EFFICIENCY
REDUCTION
Summary A uniform graphene nanodots inlaid porous gold electrode was prepared via ion beam sputtering deposition (IBSD) and mild corrosion chemistry. HRTEM, SEM, AFM and XPS analyses revealed the successful fabrication of graphene nanodots inlaid porous gold electrode. The as-prepared porous electrode was used as π-orbital-rich drug loading platform to fabricate an electrochemically controlled drug release system with high performance. π-orbital-rich drugs with amino mioety, like doxorubicin (DOX) and tetracycline (TC), were loaded into the graphene nanodots inlaid porous gold electrode via non-covalent π-π stacking interaction. The amino groups in DOX and TC can be easily protonated at acidic medium to become positively-charged NH3(+), which allow these drug molecules to be desorbed from the porous electrode surface via electrostatic repulsion when positive potential is applied at the electrode. The drug loading and release experiment indicated that this graphene nanodots inlaid porous gold electrode can be used to conveniently and efficiently control the drug release electrochemically. Not only did our work provide a benign method to electrochemically controlled drug release via electrostatic repulsion process, it also enlighten the promising practical applications of micro electrode as a drug carrier for precisely and efficiently controlled drug release via embedding in the body.
Language eng
DOI 10.1016/j.talanta.2015.09.020
Field of Research 030302 Nanochemistry and Supramolecular Chemistry
0301 Analytical Chemistry
0399 Other Chemical Sciences
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID ARC DP130101714
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080046

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