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Vibration mechanosignals superimposed to resistive exercise result in baseline skeletal muscle transcriptome profiles following chronic disuse in bed rest

Salanova, Michele, Gambara, Guido, Moriggi, Manuela, Vasso, Michele, Ungethuem, Ute, Belavý, Daniel L., Felsenberg, Dieter, Cerretelli, Paolo, Gelfi, Cecilia and Blottner, Dieter 2015, Vibration mechanosignals superimposed to resistive exercise result in baseline skeletal muscle transcriptome profiles following chronic disuse in bed rest, Scientific reports, vol. 5, Article Number : 17027, pp. 1-15, doi: 10.1038/srep17027.

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Title Vibration mechanosignals superimposed to resistive exercise result in baseline skeletal muscle transcriptome profiles following chronic disuse in bed rest
Author(s) Salanova, Michele
Gambara, Guido
Moriggi, Manuela
Vasso, Michele
Ungethuem, Ute
Belavý, Daniel L.ORCID iD for Belavý, Daniel L. orcid.org/0000-0002-9307-832X
Felsenberg, Dieter
Cerretelli, Paolo
Gelfi, Cecilia
Blottner, Dieter
Journal name Scientific reports
Volume number 5
Season Article Number : 17027
Start page 1
End page 15
Total pages 15
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2015
ISSN 2045-2322
Summary Disuse-induced muscle atrophy is a major concern in aging, in neuromuscular diseases, post-traumatic injury and in microgravity life sciences affecting health and fitness also of crew members in spaceflight. By using a laboratory analogue to body unloading we perform for the first time global gene expression profiling joined to specific proteomic analysis to map molecular adaptations in disused (60 days of bed rest) human soleus muscle (CTR) and in response to a resistive exercise (RE) countermeasure protocol without and with superimposed vibration mechanosignals (RVE). Adopting Affymetrix GeneChip technology we identified 235 differently transcribed genes in the CTR group (end-vs. pre-bed rest). RE comprised 206 differentially expressed genes, whereas only 51 changed gene transcripts were found in RVE. Most gene transcription and proteomic changes were linked to various key metabolic pathways (glycolysis, oxidative phosphorylation, tricarboxylic acid (TCA) cycle, lipid metabolism) and to functional contractile structures. Gene expression profiling in bed rest identified a novel set of genes explicitly responsive to vibration mechanosignals in human soleus. This new finding highlights the efficacy of RVE protocol in reducing key signs of disuse maladaptation and atrophy, and to maintain a close-to-normal skeletal muscle quality outcome following chronic disuse in bed rest.
Language eng
DOI 10.1038/srep17027
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Nature Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080148

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Created: Tue, 08 Dec 2015, 13:46:46 EST

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