Neurobehavioral burden of multiple sclerosis with nanotheranostics Sriramoju, Bhasker, Kanwar, Rupinder K. and Kanwar, Jagat R. 2015, Neurobehavioral burden of multiple sclerosis with nanotheranostics, Neuropsychiatric disease and treatment, vol. 11, pp. 2675-2689, doi: 10.2147/NDT.S82768. Attached Files Name Description MIMEType Size Downloads sriramoju-neurobehaviouralburden-2015.pdf Published version application/pdf 1.49MB 5 Title Neurobehavioral burden of multiple sclerosis with nanotheranostics Author(s) Sriramoju, Bhasker Kanwar, Rupinder K. Kanwar, Jagat R. Journal name Neuropsychiatric disease and treatment Volume number 11 Start page 2675 End page 2689 Total pages 15 Publisher Dove Medical Press Place of publication Auckland, New Zealand Publication date 2015-10-15 ISSN 1176-6328 Keyword(s) behavioral disorders behavioral tests demyelination Science & Technology Life Sciences & Biomedicine Clinical Neurology Psychiatry Neurosciences & Neurology EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS STEM-CELL TRANSPLANTATION PITUITARY-ADRENAL AXIS CENTRAL-NERVOUS-SYSTEM IN-VIVO COGNITIVE IMPAIRMENT INTERFERON BETA-1A PSYCHIATRIC MORBIDITY DEPRESSIVE SYMPTOMS CEREBROSPINAL-FLUID Summary Multiple sclerosis (MS) is a chronic demyelinating neurological disorder affecting people worldwide; women are affected more than men. MS results in serious neurological deficits along with behavioral compromise, the mechanisms of which still remain unclear. Behavioral disturbances such as depression, anxiety, cognitive impairment, psychosis, euphoria, sleep disturbances, and fatigue affect the quality of life in MS patients. Among these, depression and psychosis are more common than any other neurological disorders. In addition, depression is associated with other comorbidities. Although anxiety is often misdiagnosed in MS patients, it can induce suicidal ideation if it coexists with depression. An interrelation between sleep abnormalities and fatigue is also reported among MS patients. In addition, therapeutics for MS is always a challenge because of the presence of the blood-brain barrier, adding to the lack of detailed understanding of the disease pathology. In this review, we tried to summarize various behavioral pathologies and their association with MS, followed by its conventional treatment and nanotheranostics. Language eng DOI 10.2147/NDT.S82768 Field of Research 1103 Clinical Sciences 1109 Neurosciences 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 920299 Health and Support Services not elsewhere classified HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2015, The Authors Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30080173 Document type: Journal Article Collections: School of Medicine Open Access Collection Related Links Link Description Connect to published version Go to link with your DU access privileges   Connect to Elements publication management system Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Wed, 09 Dec 2015, 13:28:30 EST Thu, 10 Dec 2015, 04:01:22 EST Fri, 11 Dec 2015, 10:10:22 EST Tue, 05 Jan 2016, 05:25:29 EST Wed, 29 Jun 2016, 10:47:30 EST Tue, 05 Jul 2016, 12:51:57 EST Thu, 22 Sep 2016, 16:43:36 EST Fri, 24 Mar 2017, 14:55:10 EST Filtered Full Citation counts:   Cited 2 times in TR Web of Science Cited 2 times in Scopus Search Google Scholar Access Statistics: 80 Abstract Views, 6 File Downloads  -  Detailed Statistics Created: Wed, 09 Dec 2015, 13:28:30 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.