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Uteroplacental insufficiency leads to hypertension, but not glucose intolerance or impaired skeletal muscle mitochondrial biogenesis, in 12-month-old rats

Tran, Melanie, Young, Margaret E., Jefferies, Andrew J., Hryciw, Deanne H., Ward, Michelle M., Fletcher, Erica L., Wlodek, Mary E. and Wadley, Glenn D. 2015, Uteroplacental insufficiency leads to hypertension, but not glucose intolerance or impaired skeletal muscle mitochondrial biogenesis, in 12-month-old rats, Physiological reports, vol. 3, no. 9, Article Number : e12556, pp. 1-9, doi: 10.14814/phy2.12556.

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Title Uteroplacental insufficiency leads to hypertension, but not glucose intolerance or impaired skeletal muscle mitochondrial biogenesis, in 12-month-old rats
Author(s) Tran, Melanie
Young, Margaret E.
Jefferies, Andrew J.
Hryciw, Deanne H.
Ward, Michelle M.
Fletcher, Erica L.
Wlodek, Mary E.
Wadley, Glenn D.ORCID iD for Wadley, Glenn D. orcid.org/0000-0002-6617-4359
Journal name Physiological reports
Volume number 3
Issue number 9
Season Article Number : e12556
Start page 1
End page 9
Total pages 9
Publisher Wiley
Place of publication London, Eng.
Publication date 2015-09
ISSN 2051-817X
Keyword(s) Aging
development
fetal programming
Summary Growth restriction impacts on offspring development and increases their risk of disease in adulthood which is exacerbated with "second hits." The aim of this study was to investigate if blood pressure, glucose tolerance, and skeletal muscle mitochondrial biogenesis were altered in 12-month-old male and female offspring with prenatal or postnatal growth restriction. Bilateral uterine vessel ligation induced uteroplacental insufficiency and growth restriction in offspring (Restricted). A sham surgery was also performed during pregnancy (Control) and some litters from sham mothers had their litter size reduced (Reduced litter), which restricted postnatal growth. Growth-restricted females only developed hypertension at 12 months, which was not observed in males. In Restricted females only homeostasis model assessment for insulin resistance was decreased, indicating enhanced hepatic insulin sensitivity, which was not observed in males. Plasma leptin was increased only in the Reduced males at 12 months compared to Control and Restricted males, which was not observed in females. Compared to Controls, leptin, ghrelin, and adiponectin were unaltered in the Restricted males and females, suggesting that at 12 months of age the reduction in body weight in the Restricted offspring is not a consequence of circulating adipokines. Skeletal muscle PGC-1α levels were unaltered in 12-month-old male and female rats, which indicate improvements in lean muscle mass by 12 months of age. In summary, sex strongly impacts the cardiometabolic effects of growth restriction in 12-month-old rats and it is females who are at particular risk of developing long-term hypertension following growth restriction.
Language eng
DOI 10.14814/phy2.12556
Field of Research 111102 Dietetics and Nutrigenomics
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080234

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