Deploying aptameric sensing technology for rapid pandemic monitoring

Acquah, Caleb, Danquah, Michael K., Agyei, Dominic, Moy, Charles K. S., Sidhu, Amandeep and Ongkudon, Clarence M. 2016, Deploying aptameric sensing technology for rapid pandemic monitoring, Critical reviews in biotechnology, vol. 36, no. 6, pp. 1010-1022, doi: 10.3109/07388551.2015.1083940.

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Title Deploying aptameric sensing technology for rapid pandemic monitoring
Author(s) Acquah, Caleb
Danquah, Michael K.
Agyei, DominicORCID iD for Agyei, Dominic
Moy, Charles K. S.
Sidhu, Amandeep
Ongkudon, Clarence M.
Journal name Critical reviews in biotechnology
Volume number 36
Issue number 6
Start page 1010
End page 1022
Total pages 13
Publisher Taylor & Francis
Place of publication Abingdon, Eng.
Publication date 2016
ISSN 0738-8551
Keyword(s) aptamers
cell culture
molecular diagnostics
Summary The genome of virulent strains may possess the ability to mutate by means of antigenic shift and/or antigenic drift as well as being resistant to antibiotics with time. The outbreak and spread of these virulent diseases including avian influenza (H1N1), severe acute respiratory syndrome (SARS-Corona virus), cholera (Vibrio cholera), tuberculosis (Mycobacterium tuberculosis), Ebola hemorrhagic fever (Ebola Virus) and AIDS (HIV-1) necessitate urgent attention to develop diagnostic protocols and assays for rapid detection and screening. Rapid and accurate detection of first cases with certainty will contribute significantly in preventing disease transmission and escalation to pandemic levels. As a result, there is a need to develop technologies that can meet the heavy demand of an all-embedded, inexpensive, specific and fast biosensing for the detection and screening of pathogens in active or latent forms to offer quick diagnosis and early treatments in order to avoid disease aggravation and unnecessary late treatment costs. Nucleic acid aptamers are short, single-stranded RNA or DNA sequences that can selectively bind to specific cellular and biomolecular targets. Aptamers, as new-age bioaffinity probes, have the necessary biophysical characteristics for improved pathogen detection. This article seeks to review global pandemic situations in relation to advances in pathogen detection systems. It particularly discusses aptameric biosensing and establishes application opportunities for effective pandemic monitoring. Insights into the application of continuous polymeric supports as the synthetic base for aptamer coupling to provide the needed convective mass transport for rapid screening is also presented.
Language eng
DOI 10.3109/07388551.2015.1083940
Field of Research 100402 Medical Biotechnology Diagnostics (incl Biosensors)
Socio Economic Objective 920203 Diagnostic Methods
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Taylor & Francis
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