Increased erythrocyte eicosapentaenoic acid and docosahexaenoic acid are associated with improved attention and behavior in children with ADHD in a randomized controlled three-way crossover trial Milte, Catherine M., Parletta, Natalie, Buckley, Jonathan D., Coates, Alison M., Young, Ross M. and Howe, Peter R.C. 2015, Increased erythrocyte eicosapentaenoic acid and docosahexaenoic acid are associated with improved attention and behavior in children with ADHD in a randomized controlled three-way crossover trial, Journal of attention disorders, vol. 19, no. 11, pp. 954-964, doi: 10.1177/1087054713510562. Attached Files Name Description MIMEType Size Downloads milte-increasederythrocyte-post-2015.pdf Accepted version application/pdf 440.45KB 135 Title Increased erythrocyte eicosapentaenoic acid and docosahexaenoic acid are associated with improved attention and behavior in children with ADHD in a randomized controlled three-way crossover trial Author(s) Milte, Catherine M. orcid.org/0000-0003-0035-6405 Parletta, Natalie Buckley, Jonathan D. Coates, Alison M. Young, Ross M. Howe, Peter R.C. Journal name Journal of attention disorders Volume number 19 Issue number 11 Start page 954 End page 964 Total pages 11 Publisher Sage Publications Place of publication Thousand Oaks, Calif. Publication date 2015-11 ISSN 1087-0547 1557-1246 Keyword(s) ADD/ADHD behavior cognition fatty acid nutrition Summary OBJECTIVE: To investigate effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on attention, literacy, and behavior in children with ADHD. METHOD: Ninety children were randomized to consume supplements high in EPA, DHA, or linoleic acid (control) for 4 months each in a crossover design. Erythrocyte fatty acids, attention, cognition, literacy, and Conners' Parent Rating Scales (CPRS) were measured at 0, 4, 8, 12 months. RESULTS: Fifty-three children completed the treatment. Outcome measures showed no significant differences between the three treatments. However, in children with blood samples (n = 76-46), increased erythrocyte EPA + DHA was associated with improved spelling (r = .365, p < .001) and attention (r = -.540, p < .001) and reduced oppositional behavior (r = -.301, p < .003), hyperactivity (r = -.310, p < .001), cognitive problems (r = -.326, p < .001), Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) hyperactivity (r = -.270, p = .002) and DSM-IV inattention (r = -.343, p < .001). CONCLUSION: Increasing erythrocyte DHA and EPA via dietary supplementation may improve behavior, attention, and literacy in children with ADHD. Language eng DOI 10.1177/1087054713510562 Field of Research 1701 Psychology Socio Economic Objective 920501 Child Health HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2013, The Authors Free to Read? Yes Free to Read Start Date 2016-12-01 Persistent URL http://hdl.handle.net/10536/DRO/DU:30080286 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Wed, 16 Dec 2015, 09:15:16 EST Tue, 19 Jul 2016, 16:34:43 EST Wed, 20 Jul 2016, 05:00:38 EST Wed, 20 Jul 2016, 06:09:29 EST Wed, 20 Jul 2016, 11:35:59 EST Wed, 20 Jul 2016, 11:40:26 EST Fri, 03 Feb 2017, 14:54:27 EST Tue, 02 May 2017, 09:58:07 EST Fri, 07 Sep 2018, 12:20:21 EST Filtered Full Citation counts:   Cited 25 times in TR Web of Science Cited 29 times in Scopus Search Google Scholar Access Statistics: 386 Abstract Views, 137 File Downloads  -  Detailed Statistics Created: Tue, 19 Jul 2016, 16:34:43 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.