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Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses

Eid, Sahar G., Mangan,Niamh E., Hertzog, Paul J. and Mak, Johnson 2015, Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses, Clinical and translational immunology, vol. 4, no. 10, pp. 1-9, doi: 10.1038/cti.2015.23.

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Title Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses
Author(s) Eid, Sahar G.
Mangan,Niamh E.
Hertzog, Paul J.
Mak, JohnsonORCID iD for Mak, Johnson orcid.org/0000-0002-5229-5707
Journal name Clinical and translational immunology
Volume number 4
Issue number 10
Start page 1
End page 9
Total pages 9
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2015-10-09
ISSN 2050-0068
Summary The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides' clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.
Language eng
DOI 10.1038/cti.2015.23
Field of Research 110804 Medical Virology
Socio Economic Objective 920109 Infectious Diseases
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Australasian Society for Immunology
Free to Read? Yes
Use Rights Creative Commons Attribution Non-Commercial Share Alike licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080431

Document type: Journal Article
Collections: Faculty of Health
Open Access Collection
Molecular and Medical Research
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.