You are not logged in.

Brain substrates of social decision-making in dual diagnosis: cocaine dependence and personality disorders

Verdejo-Garcia, A, Verdejo-Román, J, Albein-Urios, Natalia, Martínez-González, JM and Soriano-Mas, C 2015, Brain substrates of social decision-making in dual diagnosis: cocaine dependence and personality disorders, Addiction biology, vol. 22, pp. 1-11, doi: 10.1111/adb.12318.

Attached Files
Name Description MIMEType Size Downloads

Title Brain substrates of social decision-making in dual diagnosis: cocaine dependence and personality disorders
Author(s) Verdejo-Garcia, A
Verdejo-Román, J
Albein-Urios, NataliaORCID iD for Albein-Urios, Natalia
Martínez-González, JM
Soriano-Mas, C
Journal name Addiction biology
Volume number 22
Start page 1
End page 11
Total pages 11
Publisher Wiley
Place of publication London, Eng.
Publication date 2015
ISSN 1369-1600
Keyword(s) Functional magnetic resonance imaging
interpersonal function
multi-player games
personality disorders
social decision-making
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Substance Abuse
Summary Cocaine dependence frequently co-occurs with personality disorders, leading to increased interpersonal problems and greater burden of disease. Personality disorders are characterised by patterns of thinking and feeling that divert from social expectations. However, the comorbidity between cocaine dependence and personality disorders has not been substantiated by measures of brain activation during social decision-making. We applied functional magnetic resonance imaging to compare brain activations evoked by a social decision-making task-the Ultimatum Game-in 24 cocaine dependents with personality disorders (CDPD), 19 cocaine dependents without comorbidities and 19 healthy controls. In the Ultimatum Game participants had to accept or reject bids made by another player to split monetary stakes. Offers varied in fairness (in fair offers the proposer shares ~50 percent of the money; in unfair offers the proposer shares <30 percent of the money), and participants were told that if they accept both players get the money, and if they reject both players lose it. We contrasted brain activations during unfair versus fair offers and accept versus reject choices. During evaluation of unfair offers CDPD displayed lower activation in the insula and the anterior cingulate cortex and higher activation in the lateral orbitofrontal cortex and superior frontal and temporal gyri. Frontal activations negatively correlated with emotion recognition. During rejection of offers CDPD displayed lower activation in the anterior cingulate cortex, striatum and midbrain. Dual diagnosis is linked to hypo-activation of the insula and anterior cingulate cortex and hyper-activation of frontal-temporal regions during social decision-making, which associates with poorer emotion recognition.
Language eng
DOI 10.1111/adb.12318
Field of Research 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Socio Economic Objective 920414 Substance Abuse
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Society for the Study of Addiction
Persistent URL

Document type: Journal Article
Collection: School of Psychology
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in TR Web of Science
Scopus Citation Count Cited 2 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 40 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Tue, 05 Jan 2016, 15:11:44 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact