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Brain substrates of social decision-making in dual diagnosis: cocaine dependence and personality disorders

Verdejo-Garcia, Antonio, Verdejo-Román, Juan, Albein-Urios, Natalia, Martínez-González, Jose M. and Soriano-Mas, Carles 2015, Brain substrates of social decision-making in dual diagnosis: cocaine dependence and personality disorders, Addiction biology, Early view, pp. 1-11, doi: 10.1111/adb.12318.

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Title Brain substrates of social decision-making in dual diagnosis: cocaine dependence and personality disorders
Author(s) Verdejo-Garcia, Antonio
Verdejo-Román, Juan
Albein-Urios, NataliaORCID iD for Albein-Urios, Natalia orcid.org/0000-0001-7841-018X
Martínez-González, Jose M.
Soriano-Mas, Carles
Journal name Addiction biology
Season Early view
Start page 1
End page 11
Total pages 11
Publisher Wiley
Place of publication London, Eng.
Publication date 2015
ISSN 1369-1600
Keyword(s) functional magnetic resonance imaging
interpersonal function
multi-player games
personality disorders
social decision-making
Summary Cocaine dependence frequently co-occurs with personality disorders, leading to increased interpersonal problems and greater burden of disease. Personality disorders are characterised by patterns of thinking and feeling that divert from social expectations. However, the comorbidity between cocaine dependence and personality disorders has not been substantiated by measures of brain activation during social decision-making. We applied functional magnetic resonance imaging to compare brain activations evoked by a social decision-making task-the Ultimatum Game-in 24 cocaine dependents with personality disorders (CDPD), 19 cocaine dependents without comorbidities and 19 healthy controls. In the Ultimatum Game participants had to accept or reject bids made by another player to split monetary stakes. Offers varied in fairness (in fair offers the proposer shares ~50 percent of the money; in unfair offers the proposer shares <30 percent of the money), and participants were told that if they accept both players get the money, and if they reject both players lose it. We contrasted brain activations during unfair versus fair offers and accept versus reject choices. During evaluation of unfair offers CDPD displayed lower activation in the insula and the anterior cingulate cortex and higher activation in the lateral orbitofrontal cortex and superior frontal and temporal gyri. Frontal activations negatively correlated with emotion recognition. During rejection of offers CDPD displayed lower activation in the anterior cingulate cortex, striatum and midbrain. Dual diagnosis is linked to hypo-activation of the insula and anterior cingulate cortex and hyper-activation of frontal-temporal regions during social decision-making, which associates with poorer emotion recognition.
Language eng
DOI 10.1111/adb.12318
Field of Research 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Socio Economic Objective 920414 Substance Abuse
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Society for the Study of Addiction
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080432

Document type: Journal Article
Collection: School of Psychology
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