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Cancer stem cell targeted therapy: progress amid controversies

Wang, Tao, Shigdar, Sarah, Gantier, Michael P., Hou, Yingchun, Wang, Li, Li, Yong, Al Shamaileh, Hadi, Yin, Wang, Zhou, Shu Feng, Zhao, Xinhan and Duan, Wei 2015, Cancer stem cell targeted therapy: progress amid controversies, Oncotarget, vol. 6, no. 42, pp. 44191-44206, doi: 10.18632/oncotarget.6176.

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Title Cancer stem cell targeted therapy: progress amid controversies
Author(s) Wang, Tao
Shigdar, Sarah
Gantier, Michael P.
Hou, Yingchun
Wang, Li
Li, Yong
Al Shamaileh, Hadi
Yin, Wang
Zhou, Shu Feng
Zhao, Xinhan
Duan, Wei
Journal name Oncotarget
Volume number 6
Issue number 42
Start page 44191
End page 44206
Total pages 16
Publisher Impact Journals
Place of publication Albany, N.Y.
Publication date 2015-10-19
ISSN 1949-2553
Keyword(s) anti-cancer treatment
cancer
cancer stem cell
cancer stem cell marker
cancer stem cell model
Summary Although cancer stem cells have been well characterized in numerous malignancies, the fundamental characteristics of this group of cells, however, have been challenged by some recent observations: cancer stem cells may not necessary to be rare within tumors; cancer stem cells and non-cancer stem cells may undergo reversible phenotypic changes; and the cancer stem cells phenotype can vary substantially between patients. Here the current status and progresses of cancer stem cells theory is illustrated and via providing a panoramic view of cancer therapy, we addressed the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy.
Language eng
DOI 10.18632/oncotarget.6176
Field of Research 111204 Cancer Therapy (excl Chemotherapy and Radiation Therapy)
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080436

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.