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Cocaine-specific neuroplasticity in the ventral striatum network is linked to delay discounting and drug relapse

Contreras-Rodríguez, Oren, Albein-Urios, Natalia, Perales, Jose, Martínez-Gonzalez, Jose M., Vilar-López, Raquel, Fernández-Serrano, Maria J., Lozano-Rojas, Oscar and Verdejo-García, Antonio 2015, Cocaine-specific neuroplasticity in the ventral striatum network is linked to delay discounting and drug relapse, Addiction, vol. 110, no. 12, pp. 1953-1962, doi: 10.1111/add.13076.

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Title Cocaine-specific neuroplasticity in the ventral striatum network is linked to delay discounting and drug relapse
Author(s) Contreras-Rodríguez, Oren
Albein-Urios, Natalia
Perales, Jose
Martínez-Gonzalez, Jose M.
Vilar-López, Raquel
Fernández-Serrano, Maria J.
Lozano-Rojas, Oscar
Verdejo-García, Antonio
Journal name Addiction
Volume number 110
Issue number 12
Start page 1953
End page 1962
Total pages 10
Publisher Wiley
Place of publication London, Eng.
Publication date 2015-12
ISSN 1360-0443
Keyword(s) Cocaine
compulsivity
gambling
impulsivity
relapse
striatum
Science & Technology
Life Sciences & Biomedicine
Substance Abuse
Psychiatry
SUBSTANCE-USE DISORDERS
FUNCTIONAL CONNECTIVITY
DEPENDENT INDIVIDUALS
PREFRONTAL CORTEX
NUCLEUS-ACCUMBENS
DECISION-MAKING
PREDICTS
ADDICTION
CHOICE
Summary AIMS: To contrast functional connectivity on ventral and dorsal striatum networks in cocaine dependence relative to pathological gambling, via a resting-state functional connectivity approach; and to determine the association between cocaine dependence-related neuroadaptations indexed by functional connectivity and impulsivity, compulsivity and drug relapse. DESIGN: Cross-sectional study of 20 individuals with cocaine dependence (CD), 19 individuals with pathological gambling (PG) and 21 healthy controls (HC), and a prospective cohort study of 20 CD followed-up for 12 weeks to measure drug relapse. SETTING AND PARTICIPANTS: CD and PG were recruited through consecutive admissions to a public clinic specialized in substance addiction treatment (Centro Provincial de Drogodependencias) and a public clinic specialized in gambling treatment (AGRAJER), respectively; HC were recruited through community advertisement in the same area in Granada (Spain). MEASUREMENTS: Seed-based functional connectivity in the ventral striatum (ventral caudate and ventral putamen) and dorsal striatum (dorsal caudate and dorsal putamen), the Kirby delay-discounting questionnaire, the reversal-learning task and a dichotomous measure of cocaine relapse indicated with self-report and urine tests. FINDINGS: CD relative to PG exhibit enhanced connectivity between the ventral caudate seed and subgenual anterior cingulate cortex, the ventral putamen seed and dorsomedial pre-frontal cortex and the dorsal putamen seed and insula (P≤0.001, kE=108). Connectivity between the ventral caudate seed and subgenual anterior cingulate cortex is associated with steeper delay discounting (P≤0.001, kE=108) and cocaine relapse (P≤0.005, kE=34). CONCLUSIONS: Cocaine dependence-related neuroadaptations in the ventral striatum of the brain network are associated with increased impulsivity and higher rate of cocaine relapse.
Language eng
DOI 10.1111/add.13076
Field of Research 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Socio Economic Objective 920414 Substance Abuse
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080446

Document type: Journal Article
Collection: School of Psychology
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