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Ultra-small algal chitosan ocular nanoparticles with iron-binding milk protein prevents the toxic effects of carbendazim pesticide

Sunkireddy, Pavan, Kanwar, Rupinder Kaur, Ram, Jagat and Kanwar, Jagat Rakesh 2015, Ultra-small algal chitosan ocular nanoparticles with iron-binding milk protein prevents the toxic effects of carbendazim pesticide, Nanomedicine, vol. 11, no. 5, pp. 495-511, doi: 10.2217/nnm.15.205.

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Title Ultra-small algal chitosan ocular nanoparticles with iron-binding milk protein prevents the toxic effects of carbendazim pesticide
Author(s) Sunkireddy, Pavan
Kanwar, Rupinder Kaur
Ram, Jagat
Kanwar, Jagat Rakesh
Journal name Nanomedicine
Volume number 11
Issue number 5
Start page 495
End page 511
Total pages 17
Publisher Future Medicine
Place of publication London England
Publication date 2015-03
ISSN 1748-6963
Keyword(s) Apoptosis
Bovine lactoferrin
Carbendazim
Nanoencapsulation
Ocular drug delivery
Oxidative stress
Topical administration
Ultra-small algal chitosan nanoparticles
Aptosis
Summary AIM: To fabricate ultra-small algal chitosan nanoparticles (US CS NPs) for efficient delivery of bovine lactoferrin (bLf) to ocular tissues through topical administration to prevent carbendazim-induced toxicity. MATERIALS & METHODS: Rat eye model was used to evaluate the in vivo biodistribution the US CS NPs and bovine eye model was used for evaluating ex vivo biodistribution. Human lens epithelial cell line (HLEB-3) model was used to evaluate the in vitro toxicity, uptake mechanism and in vitro efficacy of the synthesized bLf-US CS NPs over carbendazim-induced ocular toxicity. RESULTS: The in vivo and ex vivo biodistribution results suggest that the ultra-small CS NPs efficiently internalize into the ocular tissues within 1 h after administering topically. Ultra-small algal nanocarriers to encapsulate bioactive antioxidant bLf protein and evaluated its potential in inhibiting carbendazim-induced human lens cell apoptosis and oxidative stress. CONCLUSION: US CS NPs could be explored for their potential for delivering various ocular drugs through topical administration for other eye diseases including cataract, glaucoma and age-related macular degeneration.
Language eng
DOI 10.2217/nnm.15.205
Field of Research 1004 Medical Biotechnology
1007 Nanotechnology
111799 Public Health and Health Services not elsewhere classified
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Future Medicine
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080473

Document type: Journal Article
Collection: School of Medicine
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