Regional homogeneity of resting-state brain abnormalities in violent juvenile offenders: A biomarker of brain immaturity?

Chen, Chen, Zhou, Jiansong, Liu, Chunhong, Witt, Katrina, Zhang, Yingdong, Jing, Bin, Li, Chun, Wang, Xiaoping and Li, Lingjang 2015, Regional homogeneity of resting-state brain abnormalities in violent juvenile offenders: A biomarker of brain immaturity?, Journal of neuropsychiatry and clinical neurosciences, vol. 27, no. 1, Winter, pp. 27-32, doi: 10.1176/appi.neuropsych.13030044.

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Title Regional homogeneity of resting-state brain abnormalities in violent juvenile offenders: A biomarker of brain immaturity?
Author(s) Chen, Chen
Zhou, Jiansong
Liu, Chunhong
Witt, Katrina
Zhang, Yingdong
Jing, Bin
Li, Chun
Wang, Xiaoping
Li, Lingjang
Journal name Journal of neuropsychiatry and clinical neurosciences
Volume number 27
Issue number 1
Season Winter
Start page 27
End page 32
Total pages 6
Publisher American Psychiatric Press
Place of publication Washington, D.C.
Publication date 2015-01
ISSN 0895-0172
1545-7222
Summary The authors investigated whether male violent juvenile offenders demonstrate any differences in local functional connectivity indicative of delayed maturation of the brain that may serve as a biomarker of violence. Twenty-nine violent juvenile offenders and 28 age-matched controls were recruited. Regional homogeneity (ReHo) method was used to analyze resting-state magnetic resonance images. Violent offenders showed significantly lower ReHo values in the right caudate, right medial prefrontal cortex, and left precuneus, and higher values in the right supramarginal gyrus than the controls. These regions had both high sensitivity and specificity in distinguishing between the two groups suggesting that dysfunction in these regions can be used to correctly classify those individuals who are violent. Dysfunction in the right medial prefrontal-caudate circuit may, therefore, represent an important biomarker of violence juvenile males.
Language eng
DOI 10.1176/appi.neuropsych.13030044
Field of Research 1103 Clinical Sciences
1109 Neurosciences
1702 Cognitive Science
170104 Forensic Psychology
Socio Economic Objective 920410 Mental Health
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2015, American Psychiatric Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080505

Document type: Journal Article
Collection: School of Health and Social Development
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