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Development of a sustained release solid dispersion using swellable polymer by melting method

Nguyen, Tuong Nfoc-Gia, Tran, Phuong Ha-Lien, Van Vo, Toi, Duan, Wei and Tran, Truong-Dinh Thao 2016, Development of a sustained release solid dispersion using swellable polymer by melting method, Pharmaceutical research, vol. 33, no. 1, pp. 102-109, doi: 10.1007/s11095-015-1767-2.

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Title Development of a sustained release solid dispersion using swellable polymer by melting method
Author(s) Nguyen, Tuong Nfoc-Gia
Tran, Phuong Ha-Lien
Van Vo, Toi
Duan, Wei
Tran, Truong-Dinh Thao
Journal name Pharmaceutical research
Volume number 33
Issue number 1
Start page 102
End page 109
Total pages 8
Publisher Springer
Place of publication Berlin, Germany
Publication date 2016-01
ISSN 1573-904X
Keyword(s) poorly water-soluble drug
solid dispersion
sustained release
swellable polymer
Science & Technology
Physical Sciences
Life Sciences & Biomedicine
Chemistry, Multidisciplinary
Pharmacology & Pharmacy
Chemistry
DRUG-RELEASE
POLY(ETHYLENE OXIDE)
DELIVERY
MATRICES
DISSOLUTION
ISRADIPINE
HPMC
BIOAVAILABILITY
HYPROMELLOSE
SOLUBILITY
Summary PURPOSE: This study is to design a sustained release solid dispersion using swellable polymer by melting method. METHODS: Polyethylene glycol 6000 (PEG 6000) and hydroxypropyl methylcellulose 4000 (HPMC 4000) were used in solid dispersion for not only enhancing drug dissolution rate but also sustaining drug release. HPMC 4000 is a common swellable polymer in matrix sustained release dosage form, but could not be used in preparation of solid dispersion by melting method. However, the current study utilized the swelling capability of HPMC 4000 accompanied by the common carrier PEG 6000 in solid dispersion to accomplish the goal. RESULTS: While PEG 6000 acted as a releasing stimulant carrier and provided an environment to facilitate the swelling of HPMC 4000, this swellable polymer could act as a rate-controlling agent. This greatly assisted the dissolution enhancement by changing the crystalline structure of drug to more amorphous form and creating a molecular interaction. CONCLUSIONS: These results suggested that this useful technique can be applied in designing a sustained release solid dispersion with many advantages.
Language eng
DOI 10.1007/s11095-015-1767-2
Field of Research 111504 Pharmaceutical Sciences
1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080597

Document type: Journal Article
Collection: School of Medicine
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Created: Wed, 06 Jul 2016, 10:00:47 EST

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