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Maternal prenatal mental health and placental 11β-HSD2 gene expression: initial findings from the mercy pregnancy and emotional wellbeing study

Seth, Sunaina, Lewis, Andrew James, Saffery, Richard, Lappas, Martha and Galbally, Megan 2015, Maternal prenatal mental health and placental 11β-HSD2 gene expression: initial findings from the mercy pregnancy and emotional wellbeing study, International journal of molecular science, vol. 16, no. 11, pp. 27482-27496, doi: 10.3390/ijms161126034.

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Title Maternal prenatal mental health and placental 11β-HSD2 gene expression: initial findings from the mercy pregnancy and emotional wellbeing study
Author(s) Seth, Sunaina
Lewis, Andrew James
Saffery, Richard
Lappas, Martha
Galbally, Megan
Journal name International journal of molecular science
Volume number 16
Issue number 11
Start page 27482
End page 27496
Total pages 15
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2015-11-17
ISSN 1422-0067
Keyword(s) 11-beta hydroxysteroid dehydrogenase type 2
HSD11B2
cortisol
fetal programming
placenta 11β-HSD2
prenatal anxiety
prenatal depression
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
Chemistry
placenta 11-HSD2
11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2
POSTNATAL DEPRESSION SCALE
INTRAUTERINE GROWTH RESTRICTION
MESSENGER-RNA EXPRESSION
EPIGENETIC REGULATION
COMMUNITY SAMPLE
PLASMA-CORTISOL
ANXIETY
STRESS
VALIDATION
Summary High intrauterine cortisol exposure can inhibit fetal growth and have programming effects for the child's subsequent stress reactivity. Placental 11beta-hydroxysteroid dehydrogenase (11β-HSD2) limits the amount of maternal cortisol transferred to the fetus. However, the relationship between maternal psychopathology and 11β-HSD2 remains poorly defined. This study examined the effect of maternal depressive disorder, antidepressant use and symptoms of depression and anxiety in pregnancy on placental 11β-HSD2 gene (HSD11B2) expression. Drawing on data from the Mercy Pregnancy and Emotional Wellbeing Study, placental HSD11B2 expression was compared among 33 pregnant women, who were selected based on membership of three groups; depressed (untreated), taking antidepressants and controls. Furthermore, associations between placental HSD11B2 and scores on the State-Trait Anxiety Inventory (STAI) and Edinburgh Postnatal Depression Scale (EPDS) during 12-18 and 28-34 weeks gestation were examined. Findings revealed negative correlations between HSD11B2 and both the EPDS and STAI (r = -0.11 to -0.28), with associations being particularly prominent during late gestation. Depressed and antidepressant exposed groups also displayed markedly lower placental HSD11B2 expression levels than controls. These findings suggest that maternal depression and anxiety may impact on fetal programming by down-regulating HSD11B2, and antidepressant treatment alone is unlikely to protect against this effect.
Language eng
DOI 10.3390/ijms161126034
Field of Research 0399 Other Chemical Sciences
0604 Genetics
0699 Other Biological Sciences
170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080617

Document type: Journal Article
Collections: School of Psychology
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.