Linking the serotonin transporter gene, family environments, hippocampal volume and depression onset: a prospective imaging gene × environment analysis

Little, Keriann, Olsson, Craig A., Youssef, George J., Whittle, Sarah, Simmons, Julian G., Yücel, Murat, Sheeber, Lisa B., Foley, Debra L. and Allen, Nicholas B. 2015, Linking the serotonin transporter gene, family environments, hippocampal volume and depression onset: a prospective imaging gene × environment analysis, Journal of abnormal psychology, vol. 124, no. 4, pp. 834-849, doi: 10.1037/abn0000101.

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Title Linking the serotonin transporter gene, family environments, hippocampal volume and depression onset: a prospective imaging gene × environment analysis
Author(s) Little, Keriann
Olsson, Craig A.ORCID iD for Olsson, Craig A. orcid.org/0000-0002-5927-2014
Youssef, George J.ORCID iD for Youssef, George J. orcid.org/0000-0002-6178-4895
Whittle, Sarah
Simmons, Julian G.
Yücel, Murat
Sheeber, Lisa B.
Foley, Debra L.
Allen, Nicholas B.
Journal name Journal of abnormal psychology
Volume number 124
Issue number 4
Start page 834
End page 849
Total pages 16
Publisher American Psychological Association
Place of publication Washington, D. C.
Publication date 2015-11
ISSN 1939-1846
Keyword(s) Social Sciences
Psychology, Clinical
Psychology, Multidisciplinary
Psychology
imaging gene X environment :framework
serotonin transporter gene
major depressive disorder
family environment
hippocampus
PEDIATRIC MAJOR DEPRESSION
5-HTTLPR POLYMORPHISM
NEUROGENETICS APPROACH
STATISTICAL POWER
BRAIN-DEVELOPMENT
SEXUAL-ABUSE
LONG VARIANT
IN-VIVO
DISORDER
STRESS
Summary A single imaging gene-environment (IGxE) framework that is able to simultaneously model genetic, neurobiological, and environmental influences on psychopathology outcomes is needed to improve understanding of how complex interrelationships between allelic variation, differences in neuroanatomy or neuroactivity, and environmental experience affect risk for psychiatric disorder. In a longitudinal study of adolescent development we demonstrate the utility of such an IGxE framework by testing whether variation in parental behavior at age 12 altered the strength of an imaging genetics pathway, involving an indirect association between allelic variation in the serotonin transporter gene to variation in hippocampal volume and consequent onset of major depressive disorder by age 18. Results were consistent with the presence of an indirect effect of the serotonin transporter S-allele on depression onset via smaller left and right hippocampal volumes that was significant only in family environments involving either higher levels of parental aggression or lower levels of positive parenting. The previously reported finding of S-allele carriers' increased risk of depression in adverse environments may, therefore, be partly because of the effects of these environments on a neurobiological pathway from the serotonin transporter gene to depression onset that proceeds through variation in hippocampal volume. 
Language eng
DOI 10.1037/abn0000101
Field of Research 1701 Psychology
170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, APA
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080632

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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