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Postprandial plasma phospholipids in men are influenced by the source of dietary fat

Meikle, Peter J., Barlow, Christopher K., Mellett, Natalie A., Mundra, Piyushkumar A., Bonham, Maxine P., Larsen, Amy, Cameron-Smith, David, Sinclair, Andrew, Nestel, Paul J. and Wong, Gerard 2015, Postprandial plasma phospholipids in men are influenced by the source of dietary fat, Journal of nutrition, vol. 145, no. 9, pp. 2012-2018, doi: 10.3945/jn.115.210104.

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Title Postprandial plasma phospholipids in men are influenced by the source of dietary fat
Author(s) Meikle, Peter J.
Barlow, Christopher K.
Mellett, Natalie A.
Mundra, Piyushkumar A.
Bonham, Maxine P.
Larsen, Amy
Cameron-Smith, David
Sinclair, Andrew
Nestel, Paul J.
Wong, Gerard
Journal name Journal of nutrition
Volume number 145
Issue number 9
Start page 2012
End page 2018
Total pages 7
Publisher American Society for Nutrition
Place of publication Rockville, Md
Publication date 2015-07-15
ISSN 1541-6100
Keyword(s) dairy
humans
lipidomics
mass spectrometry
phospholipids
soy
Summary BACKGROUND: Postprandial lipemia represents a risk factor for chronic diseases, including type 2 diabetes. Little is known about the effect of dietary fat on the plasma lipidome in the postprandial period. OBJECTIVE: The objective of this study was to assess the effect of dairy fat and soy oil on circulating postprandial lipids in men. METHODS: Men (40-60 y old, nonsmokers; n = 16) were randomly assigned in a crossover design to consume 2 breakfast meals of dairy-based or soy oil-based foods. The changes in the plasma lipidome during the 4-h postprandial period were analyzed with electrospray ionization tandem mass spectrometry and included 316 lipid species in 23 classes and subclasses, representing sphingolipids, phospholipids, glycerolipids, and sterols. RESULTS: Nonparametric Friedman tests showed significant changes in multiple plasma lipid classes, subclasses, and species in the postprandial period after both dairy and soy meals. No difference was found in triglyceridemia after each meal. However, 6 endogenous lipid classes increased after dairy but decreased after soy (P < 0.05), including ether-linked phospholipids and plasmalogens and sphingomyelin (not present in soy), dihexosylceramide, and GM3 ganglioside. Phosphatidylcholine and phosphatidylinositol were not affected by the soy meal but were significantly elevated after the dairy meal (8.3% and 16%, respectively; P < 0.05). CONCLUSIONS: The changes in postprandial plasma phospholipids in men relate to the diet composition and the relative size of the endogenous phospholipid pools. Despite similar lipemic responses as measured by changes in triglyceride concentrations, the differential responses to dairy and soy meals derived through lipidomic analysis of phospholipids suggest differences in the metabolism of soybean oil and dairy fat. The increased concentrations of plasmalogens, with potential antioxidant capacity, in the postprandial period after dairy but not soy meals may represent a further important difference in the response to these sources of fat. The trial was registered at www.anzctr.org.au as ACTRN12610000562077.
Language eng
DOI 10.3945/jn.115.210104
Field of Research 111103 Nutritional Physiology
1111 Nutrition And Dietetics
0702 Animal Production
0908 Food Sciences
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, American Society for Nutrition
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080641

Document type: Journal Article
Collection: Molecular and Medical Research
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