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Pro-inflammatory dietary intake as a risk factor for CVD in men: a 5-year longitudinal study

O'Neil, Adrienne, Shivappa, Nitin, Jacka, Felice N., Kotowicz, Mark A., Kibbey, Katherine, Hebert, James R. and Pasco, Julie A. 2015, Pro-inflammatory dietary intake as a risk factor for CVD in men: a 5-year longitudinal study, British journal of nutrition, vol. 114, no. 12, pp. 2074-2082, doi: 10.1017/S0007114515003815.

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Title Pro-inflammatory dietary intake as a risk factor for CVD in men: a 5-year longitudinal study
Author(s) O'Neil, Adrienne
Shivappa, Nitin
Jacka, Felice N.ORCID iD for Jacka, Felice N. orcid.org/0000-0002-9825-0328
Kotowicz, Mark A.ORCID iD for Kotowicz, Mark A. orcid.org/0000-0002-8094-1411
Kibbey, Katherine
Hebert, James R.
Pasco, Julie A.ORCID iD for Pasco, Julie A. orcid.org/0000-0002-8968-4714
Journal name British journal of nutrition
Volume number 114
Issue number 12
Start page 2074
End page 2082
Total pages 9
Publisher Cambridge University Press
Place of publication Cambridge, Eng.
Publication date 2015-12
ISSN 1475-2662
Keyword(s) CVD
DII dietary inflammatory index
Dietary inflammatory index
GOS Geelong Osteoporosis Study
Longitudinal studies
Nutrition
Risk factors
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
CORONARY-HEART-DISEASE
C-REACTIVE PROTEIN
FATTY-ACIDS
INDEX
COHORT
CHOLESTEROL
MORTALITY
PATTERNS
CANCER
Summary Convincing evidence has identified inflammation as an initiator of atherosclerosis, underpinning CVD. We investigated (i) whether dietary inflammation, as measured by the 'dietary inflammatory index (DII)', was predictive of 5-year CVD in men and (ii) its predictive ability compared with that of SFA intake alone. The sample consisted of 1363 men enrolled in the Geelong Osteoporosis Study who completed an FFQ at baseline (2001-2006) (excluding participants who were identified as having previous CVD). DII scores were computed from participants' reported intakes of carbohydrate, micronutrients and glycaemic load. DII scores were dichotomised into a pro-inflammatory diet (positive values) or an anti-inflammatory diet (negative values). The primary outcome was a formal diagnosis of CVD resulting in hospitalisation over the 5-year study period. In total, seventy-six events were observed during the 5-year follow-up period. Men with a pro-inflammatory diet at baseline were twice as likely to experience a CVD event over the study period (OR 2·07; 95 % CI 1·20, 3·55). This association held following adjustment for traditional CVD risk factors and total energy intake (adjusted OR 2·00; 95 % CI 1·03, 3·96). This effect appeared to be stronger with the inclusion of an age-by-DII score interaction. In contrast, SFA intake alone did not predict 5-year CVD events after adjustment for covariates (adjusted OR 1·40; 95 % CI 0·73, 2·70). We conclude that an association exists between a pro-inflammatory diet and CVD in Australian men. CVD clinical guidelines and public health recommendations may have to expand to include dietary patterns in the context of vascular inflammation.
Language eng
DOI 10.1017/S0007114515003815
Field of Research 0702 Animal Production
1111 Nutrition And Dietetics
0908 Food Sciences
111799 Public Health and Health Services not elsewhere classified
Socio Economic Objective 920504 Men's Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Cambridge University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080644

Document type: Journal Article
Collection: School of Medicine
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