Regulators of mitochondrial complex I activity: a review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder

Duong, Angela, Che, Yi, Ceylan, Deniz, Pinguelo, Arsene, Andreazza, Ana C., Young, L. Trevor and Berk, Michael 2016, Regulators of mitochondrial complex I activity: a review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder, Psychiatry research, vol. 236, pp. 148-157, doi: 10.1016/j.psychres.2015.12.015.

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Title Regulators of mitochondrial complex I activity: a review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder
Author(s) Duong, Angela
Che, Yi
Ceylan, Deniz
Pinguelo, Arsene
Andreazza, Ana C.
Young, L. Trevor
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Psychiatry research
Volume number 236
Start page 148
End page 157
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-02-28
ISSN 1872-7123
Keyword(s) Bipolar disorder
DJ-1
Gene expression
Microarray
Mitochondrial complex I
Mitochondrial regulators
Summary Phenomenologically, bipolar disorder (BD) is characterized by biphasic increases and decreases in energy. As this is a state-related phenomenon, identifying regulators responsible for this phasic dysregulation has the potential to uncover key elements in the pathophysiology of BD. Given the evidence suggesting mitochondrial complex I dysfunction in BD, we aimed to identify the main regulators of complex I in BD by reviewing the literature and using the published microarray data to examine their gene expression profiles. We also validated protein expression levels of the main complex I regulators by immunohistochemistry. Upon reviewing the literature, we found PARK-7, STAT-3, SIRT-3 and IMP-2 play an important role in regulating complex I activity. Published microarray studies however revealed no significant direction of regulation of STAT-3, SIRT-3, and IMP-2, but a trend towards downregulation of PARK-7 was observed in BD. Immunocontent of DJ-1 (PARK-7-encoded protein) were not elevated in post mortem prefrontal cortex from patients with BD. We also found a trend towards upregulation of DJ-1 expression with age. Our results suggest that DJ-1 is not significantly altered in BD subjects, however further studies are needed to examine DJ-1 expression levels in a cohort of older patients with BD.
Language eng
DOI 10.1016/j.psychres.2015.12.015
Field of Research 11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Socio Economic Objective 920299 Health and Support Services not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080650

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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