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Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle

Cho, Yoshitake, Hazen, Bethany C., Gandra, Paulo G., Ward, Samuel R., Schenk, Simon, Russell, Aaron P. and Kralli, Anastasia 2016, Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle, FASEB journal, vol. 30, no. 2, pp. 674-687, doi: 10.1096/fj.15-276360.

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Title Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle
Author(s) Cho, Yoshitake
Hazen, Bethany C.
Gandra, Paulo G.
Ward, Samuel R.
Schenk, Simon
Russell, Aaron P.ORCID iD for Russell, Aaron P. orcid.org/0000-0002-7323-9501
Kralli, Anastasia
Journal name FASEB journal
Volume number 30
Issue number 2
Start page 674
End page 687
Total pages 14
Publisher Federation of American Society of Experimental Biology (FASEB)
Place of publication Bethesda, Md.
Publication date 2016-02
ISSN 1530-6860
Keyword(s) angiogenesis
endurance exercise responses
oxidative metabolism
skeletal muscle plasticity
Summary Skeletal muscle mitochondrial content and oxidative capacity are important determinants of muscle function and whole-body health. Mitochondrial content and function are enhanced by endurance exercise and impaired in states or diseases where muscle function is compromised, such as myopathies, muscular dystrophies, neuromuscular diseases, and age-related muscle atrophy. Hence, elucidating the mechanisms that control muscle mitochondrial content and oxidative function can provide new insights into states and diseases that affect muscle health. In past studies, we identified Perm1 (PPARGC1- and ESRR-induced regulator, muscle 1) as a gene induced by endurance exercise in skeletal muscle, and regulating mitochondrial oxidative function in cultured myotubes. The capacity of Perm1 to regulate muscle mitochondrial content and function in vivo is not yet known. In this study, we use adeno-associated viral (AAV) vectors to increase Perm1 expression in skeletal muscles of 4-wk-old mice. Compared to control vector, AAV1-Perm1 leads to significant increases in mitochondrial content and oxidative capacity (by 40-80%). Moreover, AAV1-Perm1-transduced muscles show increased capillary density and resistance to fatigue (by 33 and 31%, respectively), without prominent changes in fiber-type composition. These findings suggest that Perm1 selectively regulates mitochondrial biogenesis and oxidative function, and implicate Perm1 in muscle adaptations that also occur in response to endurance exercise.-Cho, Y., Hazen, B. C., Gandra, P. G., Ward, S. R., Schenk, S., Russell, A. P., Kralli, A. Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle.
Language eng
DOI 10.1096/fj.15-276360
Field of Research 0601 Biochemistry And Cell Biology
0606 Physiology
1116 Medical Physiology
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, FASEB
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080657

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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