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Nano-capsules of amphiphilic poly (ethylene glycol)-block-poly (bisphenol A carbonate) copolymers via thermodynamic entrapment

Sutti, A., Chaffraix, T., Voda, A., Taylor, A. and Magniez, K. 2016, Nano-capsules of amphiphilic poly (ethylene glycol)-block-poly (bisphenol A carbonate) copolymers via thermodynamic entrapment, RSC advances, vol. 6, no. 8, pp. 6065-6071, doi: 10.1039/C5RA23555C.

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Title Nano-capsules of amphiphilic poly (ethylene glycol)-block-poly (bisphenol A carbonate) copolymers via thermodynamic entrapment
Author(s) Sutti, A.ORCID iD for Sutti, A. orcid.org/0000-0002-1793-3881
Chaffraix, T.
Voda, A.
Taylor, A.
Magniez, K.
Journal name RSC advances
Volume number 6
Issue number 8
Start page 6065
End page 6071
Total pages 7
Publisher Royal Society of Chemistry
Place of publication London, Eng.
Publication date 2016
ISSN 2046-2069
Keyword(s) Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
TRANSFER RADICAL POLYMERIZATION
ACID) BLOCK-COPOLYMERS
INTERFACIAL POLYCONDENSATION
NANOSTRUCTURED MATERIALS
SEEDED POLYMERIZATION
SWELLING METHOD
WALL GROWTH
C-13 NMR
NANOCAPSULES
ESTERIFICATION
Summary The synthesis of amphiphilic poly(ethylene glycol)-block-poly(bisphenol A carbonate) (PEG-b-PC) block copolymer is presented here using a simple bio-chemistry coupling reaction between poly(bisphenol A carbonate) (PC) with a monomethylether poly(ethylene glycol) (mPEG-OH) block, mediated by dicyclohexylcarbodiimide/4-dimethylaminopyridine. This method inherently allows great flexibility in the choice of starting materials as well as easy product purification only requiring phase separation and water washing. Collective data from Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (NMR) and modulated dynamic scanning calorimetry (MDSC) confirmed the successful attachment of the poly(ethylene glycol) (mPEG-OH) and poly(bisphenol A carbonate) (PC) blocks. The preparation of nano-capsules was carried out by sudden addition of water to PEG-b-PC copolymers dispersed in THF, resulting in the controlled precipitation (i.e. thermodynamic entrapment) of the copolymer. Nano-capsules as small as 85 nm ± 30 nm were produced using this simple and fast methodology. We also demonstrate that encapsulating a water-insoluble bisphenol A diglycidyl ether (DGEBA) epoxy resin is possible highlighting the potential use of these capsules as a chemical delivery system.
Language eng
DOI 10.1039/C5RA23555C
Field of Research 030301 Chemical Characterisation of Materials
030302 Nanochemistry and Supramolecular Chemistry
Socio Economic Objective 869999 Manufacturing not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Royal Society of Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080704

Document type: Journal Article
Collection: Institute for Frontier Materials
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