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Can cancer therapy be achieved by bridging apoptosis and autophagy: A method based on microRNA-dependent gene therapy and phytochemical targets

Vijayarathna, Soundararajan, Gothai, Sivapragasam, Jothy, Subramanion L., Chen, Yeng, Kanwar, Jagat R. and Sasidharan, Sreenivasan 2015, Can cancer therapy be achieved by bridging apoptosis and autophagy: A method based on microRNA-dependent gene therapy and phytochemical targets, Asian pacific journal of cancer prevention, vol. 16, no. 17, pp. 7435-7439, doi: 10.7314/APJCP.2015.16.17.7435.

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Title Can cancer therapy be achieved by bridging apoptosis and autophagy: A method based on microRNA-dependent gene therapy and phytochemical targets
Author(s) Vijayarathna, Soundararajan
Gothai, Sivapragasam
Jothy, Subramanion L.
Chen, Yeng
Kanwar, Jagat R.ORCID iD for Kanwar, Jagat R. orcid.org/0000-0003-3728-9568
Sasidharan, Sreenivasan
Journal name Asian pacific journal of cancer prevention
Volume number 16
Issue number 17
Start page 7435
End page 7439
Total pages 5
Publisher Asian Pacific Education Press
Place of publication Bangkok, Asia
Publication date 2015-01-01
ISSN 1513-7368
Keyword(s) Autophagy
apoptosis
microRNAs
natural remedies
Summary A failure of a cell to self destruct has long been associated with cancer progression and development. The fact that tumour cells may not instigate cell arrest or activate cell death mechanisms upon cancer drug delivery is a major concern. Autophagy is a mechanism whereby cell material can be engulfed and digested while apoptosis is a self-killing mechanism, both capable of hindering multiplication after cell injury. In particular situations, autophagy and apoptosis seem to co-exist simultaneously or interdependently with the aid of mutual proteins. This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage.
Language eng
DOI 10.7314/APJCP.2015.16.17.7435
Field of Research 1112 Oncology And Carcinogenesis
1117 Public Health And Health Services
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2015, Asian Pacific Education Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080757

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.