Inhibition of the secretion of LH in ovariectomised pigs by sustained but not repeated acute elevation of cortisol in the absence but not the presence of oestradiol

Turner, A.I., Hemsworth, P.H., Canny, B.J. and Tilbrook, A.J. 1999, Inhibition of the secretion of LH in ovariectomised pigs by sustained but not repeated acute elevation of cortisol in the absence but not the presence of oestradiol, Journal of endocrinology, vol. 163, no. 3, pp. 477-486, doi: 10.1677/joe.0.1630477.

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Title Inhibition of the secretion of LH in ovariectomised pigs by sustained but not repeated acute elevation of cortisol in the absence but not the presence of oestradiol
Author(s) Turner, A.I.ORCID iD for Turner, A.I. orcid.org/0000-0002-0682-2860
Hemsworth, P.H.
Canny, B.J.
Tilbrook, A.J.
Journal name Journal of endocrinology
Volume number 163
Issue number 3
Start page 477
End page 486
Total pages 10
Publisher Society for the Study of Reproduction
Place of publication New York, N.Y.
Publication date 1999-12
ISSN 0022-0795
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
GONADOTROPIN-RELEASING-HORMONE
LUTEINIZING-HORMONE
FOLLICULAR PHASE
RHESUS MACAQUES
ADRENAL AXIS
STRESS
GILTS
OVULATION
ESTRUS
Summary Prolonged stress is known to impair reproduction. It has been proposed that reproduction will also be impaired when a severe acute stress occurs during a period of elevated plasma concentrations of oestradiol, such as during the follicular phase of the oestrous cycle. In this experiment, we hypothesised that repeated acute and sustained elevation of cortisol would suppress the secretion of LH in ovariectomised pigs and that these effects would be enhanced in the presence of oestradiol negative feedback. Cortisol (or vehicle) was administered 12 hourly to ovariectomised pigs (n=6/treatment) for 8 days in the absence of oestradiol treatment and for a further 8 days during treatment with oestradiol. Vehicle was administered to 'control' pigs, 10 or 20 mg cortisol was administered i.v. to pigs to produce 'repeated acute' elevation of cortisol and 250 mg cortisol was administered i.m. to pigs to give a 'sustained' elevation of cortisol. Both before and during treatment with oestradiol, plasma concentrations of LH were monitored on the day before treatment, on the 4th and 8th days of treatment and following an i.v. injection of GnRH at the end of the 8th day of treatment. The repeated acute elevation of cortisol did not impair any parameters of LH secretion (i.e. mean plasma concentrations of LH, pulse amplitude or frequency, pre-LH pulse nadir or the LH response to GnRH) in the absence or in the presence of oestradiol. In contrast, when the elevation of cortisol was sustained, the mean plasma concentrations of LH and the pre-LH pulse nadir were significantly (P<0.05) lower on the 8th day of treatment than on the day before treatment and on the 4th day of treatment. Nevertheless, no other parameters of LH secretion were affected and these effects only occurred in the absence (not in the presence) of oestradiol. In conclusion, cortisol needed to be elevated for more than 4 days to impair the secretion of LH, and oestradiol did not enhance the impact of cortisol on LH secretion in ovariectomised pigs.
Language eng
DOI 10.1677/joe.0.1630477
Field of Research 070206 Animal Reproduction
110306 Endocrinology
111603 Systems Physiology
1103 Clinical Sciences
0707 Veterinary Sciences
0702 Animal Production
Socio Economic Objective 830308 Pigs
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©1999, Society for the Study of Reproduction
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080839

Document type: Journal Article
Collection: Centre for Physical Activity and Nutrition Research
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