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Stress and reproduction: central mechanisms and sex differences in non-rodent species

Tilbrook, A.J., Turner, A.I. and Clarke, I.J. 2002, Stress and reproduction: central mechanisms and sex differences in non-rodent species, Stress: the international journal on the biology of stress, vol. 5, no. 2, pp. 83-100, doi: 10.1080/10253890290027912.

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Title Stress and reproduction: central mechanisms and sex differences in non-rodent species
Author(s) Tilbrook, A.J.
Turner, A.I.
Clarke, I.J.
Journal name Stress: the international journal on the biology of stress
Volume number 5
Issue number 2
Start page 83
End page 100
Total pages 18
Publisher Taylor & Francis
Place of publication England
Publication date 2002
ISSN 1025-3890
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Behavioral Sciences
Endocrinology & Metabolism
Neurosciences
Neurosciences & Neurology
GnRH
Gonadotrophins
Sex differences
Stress
GONADOTROPIN-RELEASING-HORMONE
OVARIECTOMIZED RHESUS-MONKEY
SUPERIOR CERVICAL GANGLIONECTOMY
HYPOGLYCEMIA-INDUCED INHIBITION
INSULIN-INDUCED HYPOGLYCEMIA
ENDOGENOUS OPIOID-PEPTIDES
PULSE-GENERATOR ACTIVITY
PITUITARY-ADRENAL AXIS
ARGININE-VASOPRESSIN SECRETION
MESSENGER-RIBONUCLEIC-ACID
Summary Despite extensive research, the mechanisms by which stress affects reproduction are unknown. Activation of stress systems could potentially influence reproduction at any level of the hypothalamo-pituitary gonadal axis. Nonetheless, the predominant impact is on the secretion of gonadotrophin releasing hormone (GnRH) from the brain and the secretion of the gonadotrophins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), from the gonadotrophs of the anterior pituitary gland. When stress is prolonged, it is likely that secretion of the gonadotrophins will be suppressed but the effects of acute stress or repeated acute stress are not clear. Different stressors activate different pathways for varying durations, and the actions of stress vary with sex and are influenced by the predominance of particular sex steroids in the circulation. The mechanisms by which stress influences reproduction are likely to involve complex interactions between a number of central and peripheral pathways and may be different in males and females. To understand these mechanisms, it is important to determine the stress pathways that are activated by particular stressors and to establish how these pathways affect the secretion and actions of GnRH. Furthermore, there is a need to know how stress influences the feedback actions of gonadal steroids and inhibin.
Language eng
DOI 10.1080/10253890290027912
Field of Research 111404 Reproduction
110306 Endocrinology
111603 Systems Physiology
1103 Clinical Sciences
Socio Economic Objective 920106 Endocrine Organs and Diseases (excl. Diabetes)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2002, Taylor & Francis
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080849

Document type: Journal Article
Collection: Centre for Physical Activity and Nutrition Research
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