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Noradrenaline, but not neuropeptide Y, is elevated in cerebrospinal fluid from the third cerebral ventricle following audiovisual stress in gonadectomised rams and ewes

Turner, Anne I., Rivalland, Elizabeth T.A., Clarke, Iain J., Lambert, Gavin W., Morris, Margaret J. and Tilbrook, Alan J. 2002, Noradrenaline, but not neuropeptide Y, is elevated in cerebrospinal fluid from the third cerebral ventricle following audiovisual stress in gonadectomised rams and ewes, Neuroendocrinology, vol. 76, no. 6, pp. 373-380, doi: 10.1159/000067584.

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Title Noradrenaline, but not neuropeptide Y, is elevated in cerebrospinal fluid from the third cerebral ventricle following audiovisual stress in gonadectomised rams and ewes
Author(s) Turner, Anne I.ORCID iD for Turner, Anne I. orcid.org/0000-0002-0682-2860
Rivalland, Elizabeth T.A.
Clarke, Iain J.
Lambert, Gavin W.
Morris, Margaret J.
Tilbrook, Alan J.
Journal name Neuroendocrinology
Volume number 76
Issue number 6
Start page 373
End page 380
Total pages 8
Publisher Karger
Place of publication Basel, Switzerland
Publication date 2002-12
ISSN 0028-3835
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Neurosciences
Neurosciences & Neurology
catecholamines
stress
sex dimorphism
cerebrospinal fluid
paraventricular nucleus
ovine
HYPOTHALAMIC PARAVENTRICULAR NUCLEUS
GONADOTROPIN-RELEASING-HORMONE
PITUITARY-ADRENOCORTICAL AXIS
ARCUATE NUCLEUS
SEX-DIFFERENCES
BRAIN-STEM
NOREPINEPHRINE RELEASE
CATECHOLAMINE CONTENT
ARGININE-VASOPRESSIN
PORTAL CIRCULATION
Summary There are sex differences in the activation of the hypothalamo-pituitary-adrenal axis in response to stress, but the source of these differences is unknown. The hypothalamo-pituitary-adrenal axis is regulated by corticotropin-releasing hormone and arginine-vasopressin neurones located in the paraventricular nucleus and these, in turn, are regulated by neural systems that include afferent noradrenergic and neuropeptide Y (NPY)-producing neural pathways. We tested the hypothesis that concentrations of noradrenaline and NPY will be elevated in cerebrospinal fluid (CSF) sampled from the third cerebral ventricle in response to stress, and these responses will differ in males and females. We collected concurrent samples of CSF (1 ml) from the third ventricle and blood (5 ml) from the jugular vein from gonadectomised rams (n = 7) and ewes (n = 5) at 10-min intervals for 3 h. This procedure was conducted on a day when no stress was imposed and on a day when audiovisual stress was imposed for 5 min after 1 h of sampling. Following the audiovisual stress, plasma concentrations of cortisol and CSF concentrations of noradrenaline were elevated (p < 0.05), but CSF concentrations of NPY did not change. Adrenaline was not detected in samples of CSF. The rise in plasma cortisol following the stress was greater (p < 0.05) in ewes than in rams, but there were no sex differences in the rise in noradrenaline. Basal concentrations of NPY in the CSF were higher (p < 0.05) in rams than in ewes. We conclude that the sex differences in the stress-induced activity of the hypothalamo-pituitary-adrenal axis in sheep are not likely to be due to differences in the level of noradrenergic and/or NPY input to the hypothalamus.
Language eng
DOI 10.1159/000067584
Field of Research 110306 Endocrinology
110903 Central Nervous System
110901 Autonomic Nervous System
1103 Clinical Sciences
1109 Neurosciences
Socio Economic Objective 920106 Endocrine Organs and Diseases (excl. Diabetes)
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2002, Karger
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080852

Document type: Journal Article
Collection: Centre for Physical Activity and Nutrition Research
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