Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors

Herbert, Annie, Cruickshank, John Kennedy, Laurent, Stephane, Boutouyrie, Pierre and Macpherson, Helen 2014, Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors, European heart journal, vol. 35, no. 44, pp. 3122-3133, doi: 10.1093/eurheartj/ehu293.

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Title Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors
Author(s) Herbert, Annie
Cruickshank, John Kennedy
Laurent, Stephane
Boutouyrie, Pierre
Macpherson, HelenORCID iD for Macpherson, Helen orcid.org/0000-0002-3603-9359
Journal name European heart journal
Volume number 35
Issue number 44
Start page 3122
End page 3133
Total pages 12
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2014
ISSN 1522-9645
Keyword(s) Adult
Aged
Aorta
Arteries
Arteriosclerosis
Blood pressure
Central pressure
Humans
Pulse
Age Distribution
Blood Pressure Determination
Cardiovascular Diseases
Female
Healthy Volunteers
Male
Middle Aged
Reference Values
Risk Factors
Sex Distribution
Systole
Young Adult
Reference Values for Arterial Measurements Collaboration
Summary AIMS: Estimated central systolic blood pressure (cSBP) and amplification (Brachial SBP-cSBP) are non-invasive measures potentially prognostic of cardiovascular (CV) disease. No worldwide, multiple-device reference values are available. We aimed to establish reference values for a worldwide general population standardizing between the different available methods of measurement. How these values were significantly altered by cardiovascular risk factors (CVRFs) was then investigated. METHODS AND RESULTS: Existing data from population surveys and clinical trials were combined, whether published or not. Reference values of cSBP and amplification were calculated as percentiles for 'Normal' (no CVRFs) and 'Reference' (any CVRFs) populations. We included 45,436 subjects out of 82,930 that were gathered from 77 studies of 53 centres. Included subjects were apparently healthy, not treated for hypertension or dyslipidaemia, and free from overt CV disease and diabetes. Values of cSBP and amplification were stratified by brachial blood pressure categories and age decade in turn, both being stratified by sex. Amplification decreased with age and more so in males than in females. Sex was the most powerful factor associated with amplification with 6.6 mmHg (5.8-7.4) higher amplification in males than in females. Amplification was marginally but significantly influenced by CVRFs, with smoking and dyslipidaemia decreasing amplification, but increased with increasing levels of blood glucose. CONCLUSION: Typical values of cSBP and amplification in a healthy population and a population free of traditional CVRFs are now available according to age, sex, and brachial BP, providing values included from different devices with a wide geographical representation. Amplification is significantly influenced by CVRFs, but differently in men and women.
Language eng
DOI 10.1093/eurheartj/ehu293
Field of Research 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified
1102 Cardiovascular Medicine And Haematology
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, The Author
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080896

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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