You are not logged in.

Contrast-enhanced ultrasound evaluation of the renal microcirculation response to terlipressin in hepato-renal syndrome: a preliminary report

Schneider, Antoine G., Schelleman, Anthony, Goodwin, Mark D., Bailey, Michael, Eastwood, Glenn M. and Bellomo, Rinaldo 2015, Contrast-enhanced ultrasound evaluation of the renal microcirculation response to terlipressin in hepato-renal syndrome: a preliminary report, Renal Failure, vol. 37, no. 1, pp. 175-179, doi: 10.3109/0886022X.2014.977140.

Attached Files
Name Description MIMEType Size Downloads

Title Contrast-enhanced ultrasound evaluation of the renal microcirculation response to terlipressin in hepato-renal syndrome: a preliminary report
Author(s) Schneider, Antoine G.
Schelleman, Anthony
Goodwin, Mark D.
Bailey, Michael
Eastwood, Glenn M.
Bellomo, Rinaldo
Journal name Renal Failure
Volume number 37
Issue number 1
Start page 175
End page 179
Total pages 6
Publisher Taylor & Francis
Place of publication London, Eng.
Publication date 2015
ISSN 1525-6049
Keyword(s) contrast-enhanced ultrasonography
hepato-renal syndrome
microcirculation
renal perfusion
terlipressin
Summary BACKGROUND: Terlipressin improves renal function in some patients with type-1 hepato-renal syndrome (HRS). Renal contrast-enhanced ultrasound (CEUS), a novel imaging modality, may help to predict terlipressin responsiveness. OBJECTIVES: We used CEUS to estimate the effect of terlipressin on the renal cortical microcirculation in type-1 HRS. METHODS: We performed renal CEUS scans with destruction-replenishment sequences using Sonovue(®) (Bracco, Milano Italy) as a contrast agent at baseline and after the intravenous administration of 1 mg of terlipressin, in four patients with type-1 HRS. We analyzed video sequences offline using dedicated software. We derived a perfusion index (PI) at each time point for each patient. RESULTS: Patients 1 and 2 had severe presentation and were admitted to the intensive care unit. Both showed a marked increase in PI (+216% and + 567% of baseline) in response to terlipressin. Patients 3 and 4 had less severe presentations and had a decrease in PI (-53% and -20% of baseline) in response to terlipressin. Patients 1, 2, and 4, but not patient 3, responded to terlipressin therapy with a decrease in serum creatinine to <150 µmol/L. CONCLUSIONS: CEUS detected changes in renal cortical microcirculation in response to terlipressin and demonstrated heterogeneous microvascular responses to terlipressin. These initial proof-of-concept findings justify future investigations.
Language eng
DOI 10.3109/0886022X.2014.977140
Field of Research 1103 Clinical Sciences
Socio Economic Objective 920210 Nursing
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Informa Healthcare USA
Persistent URL http://hdl.handle.net/10536/DRO/DU:30080987

Document type: Journal Article
Collection: School of Nursing and Midwifery
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 5 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 87 Abstract Views, 4 File Downloads  -  Detailed Statistics
Created: Thu, 28 Jan 2016, 11:28:05 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.