Titanium in biomedical applications—properties and fabrication: a review

Khorasani, Amir Mahyar, Goldberg, Moshe, Doeven, Egan H. and Littlefair, Guy 2015, Titanium in biomedical applications—properties and fabrication: a review, Journal of biomaterials and tissue engineering, vol. 5, no. 8, pp. 593-619, doi: 10.1166/jbt.2015.1361.

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Title Titanium in biomedical applications—properties and fabrication: a review
Author(s) Khorasani, Amir Mahyar
Goldberg, Moshe
Doeven, Egan H.ORCID iD for Doeven, Egan H. orcid.org/0000-0003-2677-4269
Littlefair, Guy
Journal name Journal of biomaterials and tissue engineering
Volume number 5
Issue number 8
Start page 593
End page 619
Total pages 27
Publisher American Scientific Publishers
Place of publication Valencia, Calif.
Publication date 2015-08-01
ISSN 2157-9083
2157-9091
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Cell & Tissue Engineering
Cell Biology
Biocompatibility
Bioimplants Fabrication
Mechanical Properties
Osseointegration
Ti-Based Biomaterial
COMMERCIALLY PURE TITANIUM
POROUS HYDROXYAPATITE SCAFFOLDS
SHAPE-MEMORY ALLOYS
DIAMOND-LIKE CARBON
CELLS IN-VITRO
SOL-GEL METHOD
TI-TA ALLOYS
MECHANICAL-PROPERTIES
CORROSION-RESISTANCE
IMPLANT MATERIALS
Summary Ti and Ti-based alloys have unique properties such as high strength, low density and excellent corrosion resistance. These properties are essential for the manufacture of lightweight and high strength components for biomedical applications. In this paper, Ti properties such as metallurgy, mechanical properties, surface modification, corrosion resistance, biocompatibility and osseointegration in biomedical applications have been discussed. This paper also analyses the advantages and disadvantages of various Ti manufacturing processes for biomedical applications such as casting, powder metallurgy, cold and hot working, machining, laser engineering net shaping (LEN), superplastic forming, forging and ring rolling. The contributions of this research are twofold, firstly scrutinizing the behaviour of Ti and Ti-based alloys in-vivo and in-vitro experiments in biomedical applications to determine the factors leading to failure, and secondly strategies to achieve desired properties essential to improving the quality of patient outcomes after receiving surgical implants. Future research will be directed toward manufacturing of Ti for medical applications by improving the production process, for example using optimal design approaches in additive manufacturing and investigating alloys containing other materials in order to obtain better medical and mechanical characteristics.
Language eng
DOI 10.1166/jbt.2015.1361
Field of Research 091006 Manufacturing Processes and Technologies (excl Textiles)
090399 Biomedical Engineering not elsewhere classified
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, ASP
Persistent URL http://hdl.handle.net/10536/DRO/DU:30081070

Document type: Journal Article
Collections: School of Life and Environmental Sciences
School of Engineering
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