Cancer risk among people with type 1 and type 2 diabetes: disentangling true associations, detection bias, and reverse causation

Harding, Jessica L., Shaw, Jonathan E., Peeters, Anna, Cartensen, Bendix and Magliano, Dianna J. 2015, Cancer risk among people with type 1 and type 2 diabetes: disentangling true associations, detection bias, and reverse causation, Diabetes care, vol. 38, no. 2, pp. 264-270, doi: 10.2337/dc14-1996.

Attached Files
Name Description MIMEType Size Downloads

Title Cancer risk among people with type 1 and type 2 diabetes: disentangling true associations, detection bias, and reverse causation
Author(s) Harding, Jessica L.
Shaw, Jonathan E.
Peeters, AnnaORCID iD for Peeters, Anna orcid.org/0000-0003-4340-9132
Cartensen, Bendix
Magliano, Dianna J.
Journal name Diabetes care
Volume number 38
Issue number 2
Start page 264
End page 270
Total pages 7
Publisher American Diabetes Association
Place of publication Alexandria, Va.
Publication date 2015-02
ISSN 0149-5992
1935-5548
Summary  OBJECTIVE: Evidence indicates an increased risk of certain cancers among people with type 2 diabetes. Evidence for rarer cancers and for type 1 diabetes is limited. We explored the excess risk of site-specific cancer incidence and mortality among people with type 1 and type 2 diabetes, compared with the general Australian population. RESEARCH DESIGN AND METHODS: Registrants of a national diabetes registry (953,382) between 1997 and 2008 were linked to national death and cancer registries. Standardized incidence and mortality ratios (SIRs/SMRs) are reported. RESULTS: For type 1 diabetes, significant elevated SIRs were observed for pancreas, liver, esophagus, colon and rectum (females only [F]), stomach (F), thyroid (F), brain (F), lung (F), endometrium, and ovary, and decreased SIRs were observed for prostate in males. Significantly increased SMRs were observed for pancreas, liver, and kidney (males only), non-Hodgkin's lymphoma, brain (F), and endometrium. For type 2 diabetes, significant SIRs were observed for almost all site-specific cancers, with highest SIRs observed for liver and pancreas, and decreased risks for prostate and melanoma. Significant SMRs were observed for liver, pancreas, kidney, Hodgkin's lymphoma, gallbladder (F), stomach (F), and non-Hodgkin's lymphoma (F). Cancer risk was significantly elevated throughout follow-up time but was higher in the first 3 months postregistration, suggesting the presence of detection bias and/or reverse causation. CONCLUSIONS: Type 1 and type 2 diabetes are associated with an excess risk of incidence and mortality for overall and a number of site-specific cancers, and this is only partially explained by bias. We suggest that screening for cancers in diabetic patients is important.
Language eng
DOI 10.2337/dc14-1996
Field of Research 11 Medical And Health Sciences
Socio Economic Objective 920104 Diabetes
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, American Diabetes Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30081165

Document type: Journal Article
Collection: School of Health and Social Development
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 59 times in TR Web of Science
Scopus Citation Count Cited 63 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 161 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Thu, 04 Feb 2016, 14:38:56 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.