Manufacturing techniques and surface engineering of polymer based nanoparticles for targeted drug delivery to cancer Wang, Yichao, Li, Puwang, Tran, Thao Truong-Dinh, Zhang, Juan and Kong, Lingxue 2016, Manufacturing techniques and surface engineering of polymer based nanoparticles for targeted drug delivery to cancer, Nanomaterials, vol. 6, no. 2, pp. 1-18, doi: 10.3390/nano6020026. Attached Files Name Description MIMEType Size Downloads wang-manufacturingtechniques-2016.pdf Published version application/pdf 2.41MB 148 Title Manufacturing techniques and surface engineering of polymer based nanoparticles for targeted drug delivery to cancer Author(s) Wang, Yichao Li, Puwang Tran, Thao Truong-Dinh Zhang, Juan orcid.org/0000-0003-2500-406X Kong, Lingxue orcid.org/0000-0001-6219-3897 Journal name Nanomaterials Volume number 6 Issue number 2 Start page 1 End page 18 Total pages 18 Publisher MDPI Place of publication Basel, Switzerland Publication date 2016 ISSN 2079-4991 Keyword(s) nanoparticles PLGA chitosan nano/microencapsulation drug delivery top-down fabrication techniques Science & Technology Technology Nanoscience & Nanotechnology Materials Science, Multidisciplinary Science & Technology - Other Topics Materials Science nano microencapsulation TRIMETHYL CHITOSAN CHLORIDE EPITHELIAL-CELLS CACO-2 OXYGEN PLASMA TREATMENT IN-VITRO PLGA NANOPARTICLES ORAL DELIVERY THIOLATED POLYMERS CELLULAR UPTAKE MICROSPHERES RELEASE Summary The evolution of polymer based nanoparticles as a drug delivery carrier via pharmaceutical nano/microencapsulation has greatly promoted the development of nano- and micro-medicine in the past few decades. Poly(lactide-co-glycolide) (PLGA) and chitosan, which are biodegradable and biocompatible polymers, have been approved by both the Food & Drug Administration (FDA) and European Medicine Agency (EMA), making them ideal biomaterials that can be advanced from laboratory development to clinical oral and parental administrations. PLGA and chitosan encapsulated nanoparticles (NPs) have successfully been developed as new oral drug delivery systems with demonstrated high efficacy. This review aims to provide a comprehensive overview of the fabrication of PLGA and chitosan particulate systems using nano/microencapsulation methods, the current progress and the future outlooks of the nanoparticulate drug delivery systems. Especially, we focus on the formulations and nano/micro-encapsulation techniques using top-down techniques. It also addresses how the different phases including the organic and aqueous ones in the emulsion system interact with each other and subsequently influence the properties of the drug delivery system. Besides, surface modification strategies which can effectively engineer intrinsic physicochemical properties are summarised. Finally, future perspectives and potential directions of PLGA and chitosan nano/microencapsulated drug systems are outlined. Language eng DOI 10.3390/nano6020026 Field of Research 091209 Polymers and Plastics Socio Economic Objective 920102 Cancer and Related Disorders HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2016, The Authors Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30081477 Document type: Journal Article Collections: Institute for Frontier Materials Open Access Collection GTP Research Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Thu, 18 Feb 2016, 20:26:39 EST Sat, 20 Feb 2016, 04:01:39 EST Thu, 12 May 2016, 13:57:31 EST Mon, 18 Jul 2016, 15:59:56 EST Mon, 22 Aug 2016, 10:07:39 EST Mon, 22 Aug 2016, 10:12:30 EST Tue, 07 Mar 2017, 14:30:29 EST Fri, 07 Sep 2018, 12:27:01 EST Filtered Full Citation counts:   Cited 60 times in TR Web of Science Cited 67 times in Scopus Search Google Scholar Access Statistics: 413 Abstract Views, 149 File Downloads  -  Detailed Statistics Created: Thu, 18 Feb 2016, 20:26:39 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.