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Manufacturing techniques and surface engineering of polymer based nanoparticles for targeted drug delivery to cancer

Wang, Yichao, Li, Puwang, Tran, Thao Truong-Dinh, Zhang, Juan and Kong, Lingxue 2016, Manufacturing techniques and surface engineering of polymer based nanoparticles for targeted drug delivery to cancer, Nanomaterials, vol. 6, no. 2, pp. 1-18, doi: 10.3390/nano6020026.

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Title Manufacturing techniques and surface engineering of polymer based nanoparticles for targeted drug delivery to cancer
Author(s) Wang, Yichao
Li, Puwang
Tran, Thao Truong-Dinh
Zhang, Juan
Kong, Lingxue
Journal name Nanomaterials
Volume number 6
Issue number 2
Start page 1
End page 18
Total pages 18
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2016
ISSN 2079-4991
Keyword(s) nanoparticles
PLGA
chitosan
nano/microencapsulation
drug delivery
top-down fabrication techniques
Science & Technology
Technology
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Science & Technology - Other Topics
Materials Science
nano
microencapsulation
TRIMETHYL CHITOSAN CHLORIDE
EPITHELIAL-CELLS CACO-2
OXYGEN PLASMA TREATMENT
IN-VITRO
PLGA NANOPARTICLES
ORAL DELIVERY
THIOLATED POLYMERS
CELLULAR UPTAKE
MICROSPHERES
RELEASE
Summary The evolution of polymer based nanoparticles as a drug delivery carrier via pharmaceutical nano/microencapsulation has greatly promoted the development of nano- and micro-medicine in the past few decades. Poly(lactide-co-glycolide) (PLGA) and chitosan, which are biodegradable and biocompatible polymers, have been approved by both the Food & Drug Administration (FDA) and European Medicine Agency (EMA), making them ideal biomaterials that can be advanced from laboratory development to clinical oral and parental administrations. PLGA and chitosan encapsulated nanoparticles (NPs) have successfully been developed as new oral drug delivery systems with demonstrated high efficacy. This review aims to provide a comprehensive overview of the fabrication of PLGA and chitosan particulate systems using nano/microencapsulation methods, the current progress and the future outlooks of the nanoparticulate drug delivery systems. Especially, we focus on the formulations and nano/micro-encapsulation techniques using top-down techniques. It also addresses how the different phases including the organic and aqueous ones in the emulsion system interact with each other and subsequently influence the properties of the drug delivery system. Besides, surface modification strategies which can effectively engineer intrinsic physicochemical properties are summarised. Finally, future perspectives and potential directions of PLGA and chitosan nano/microencapsulated drug systems are outlined.
Language eng
DOI 10.3390/nano6020026
Field of Research 091209 Polymers and Plastics
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30081477

Document type: Journal Article
Collections: Institute for Frontier Materials
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Created: Thu, 18 Feb 2016, 20:26:39 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.