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No long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine

Licciardi, Paul V., Toh, Zheng Quan, Clutterbuck, Elizabeth A., Balloch, Anne, Marimla, Rachel A., Tikkanen, Leena, Lamb, Karen E., Bright, Kathryn J., Rabuatoka, Uraia, Tikoduadua, Lisi, Boelsen, Laura K., Dunne, Eileen M., Satzke, Catherine, Cheung, Yin Bun, Pollard, Andrew J., Russell, Fiona M. and Mulholland, Edward K. 2016, No long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine, Journal of allergy and clinical immunology, vol. 137, no. 6, pp. 1772-1779.e11, doi: 10.1016/j.jaci.2015.12.1303.

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Title No long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine
Author(s) Licciardi, Paul V.
Toh, Zheng Quan
Clutterbuck, Elizabeth A.
Balloch, Anne
Marimla, Rachel A.
Tikkanen, Leena
Lamb, Karen E.ORCID iD for Lamb, Karen E. orcid.org/0000-0001-9782-8450
Bright, Kathryn J.
Rabuatoka, Uraia
Tikoduadua, Lisi
Boelsen, Laura K.
Dunne, Eileen M.
Satzke, Catherine
Cheung, Yin Bun
Pollard, Andrew J.
Russell, Fiona M.
Mulholland, Edward K.
Journal name Journal of allergy and clinical immunology
Volume number 137
Issue number 6
Start page 1772
End page 1779.e11
Total pages 19
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-06
ISSN 0091-6749
Keyword(s) pneumococcal polysaccharide vaccine
23vPPV
hyporesponsiveness
memory B cell
opsonophagocytosis
antibody
Summary Background: A randomized controlled trial in Fiji examined theimmunogenicity and effect on nasopharyngeal carriage after 0, 1,2, or 3 doses of 7-valent pneumococcal conjugate vaccine (PCV7;Prevnar) in infancy followed by 23-valent pneumococcalpolysaccharide vaccine (23vPPV; Pneumovax) at 12 months ofage. At 18months of age, children given 23vPPVexhibitedimmunehyporesponsiveness to a micro-23vPPV (20%) challenge dose interms of serotype-specific IgG and opsonophagocytosis, while23vPPV had no effect on vaccine-type carriage.Objective: This follow-up study examined the long-term effectof the 12-month 23vPPV dose by evaluating the immuneresponse to 13-valent pneumococcal conjugate vaccine (PCV13)administration 4 to 5 years later.Methods: Blood samples from 194 children (now 5-7 years old)were taken before and 28 days after PCV13 boosterimmunization. Nasopharyngeal swabs were taken before PCV13immunization. We measured levels of serotype-specific IgG toall 13 vaccine serotypes, opsonophagocytosis for 8 vaccineserotypes, and memory B-cell responses for 18 serotypes beforeand after PCV13 immunization.Results: Paired samples were obtained from 185 children. Therewere no significant differences in the serotype-specific IgG,opsonophagocytosis, or memory B-cell response at either timepoint between children who did or did not receive 23vPPV at12 months of age. Nasopharyngeal carriage of PCV7 and23vPPV serotypes was similar among the groups. Priming with1, 2, or 3 PCV7 doses during infancy did not affect serotypespecificimmunity or carriage.Conclusion: Immune hyporesponsiveness induced by 23vPPV intoddlers does not appear to be sustained among preschoolchildren in this context and does not affect the pneumococcalcarriage rate in this age group.
Language eng
DOI 10.1016/j.jaci.2015.12.1303
Field of Research 110799 Immunology not elsewhere classified
1107 Immunology
Socio Economic Objective 920412 Preventive Medicine
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, American Academy of Allergy, Asthma & Immunology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30081494

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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