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Immune modulation by vitamin D and its relevance to food allergy

Suaini, Noor H. A., Zhang, Yuxia, Vuillermin, Peter J., Allen, Katrina J. and Harrison, Leonard C. 2015, Immune modulation by vitamin D and its relevance to food allergy, Nutrients, vol. 7, no. 8, pp. 6088-6108, doi: 10.3390/nu7085271.

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Title Immune modulation by vitamin D and its relevance to food allergy
Author(s) Suaini, Noor H. A.
Zhang, Yuxia
Vuillermin, Peter J.
Allen, Katrina J.
Harrison, Leonard C.
Journal name Nutrients
Volume number 7
Issue number 8
Start page 6088
End page 6108
Total pages 21
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2015
ISSN 2072-6643
Keyword(s) 1,25(OH)2D3
T cells
adaptive immunity
deficiency
food allergy
inflammation
innate immunity
metabolism
vitamin D
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
REGULATORY T-CELLS
PROTEIN-KINASE-C
SERUM 25-HYDROXYVITAMIN D
P450C24 CYP24 PROMOTER
D-BINDING PROTEIN
1,25-DIHYDROXYVITAMIN D-3
D-RECEPTOR
DENDRITIC CELLS
IN-VITRO
1-ALPHA,25-DIHYDROXYVITAMIN D-3
Summary Apart from its classical function in bone and calcium metabolism, vitamin D is also involved in immune regulation and has been linked to various cancers, immune disorders and allergic diseases. Within the innate and adaptive immune systems, the vitamin D receptor and enzymes in monocytes, dendritic cells, epithelial cells, T lymphocytes and B lymphocytes mediate the immune modulatory actions of vitamin D. Vitamin D insufficiency/deficiency early in life has been identified as one of the risk factors for food allergy. Several studies have observed an association between increasing latitude and food allergy prevalence, plausibly linked to lower ultraviolet radiation (UVR) exposure and vitamin D synthesis in the skin. Along with mounting epidemiological evidence of a link between vitamin D status and food allergy, mice and human studies have shed light on the modulatory properties of vitamin D on the innate and adaptive immune systems. This review will summarize the literature on the metabolism and immune modulatory properties of vitamin D, with particular reference to food allergy.
Language eng
DOI 10.3390/nu7085271
Field of Research 1111 Nutrition And Dietetics
110799 Immunology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30081498

Document type: Journal Article
Collection: School of Medicine
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