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Polymorphisms affecting vitamin D-binding protein modify the relationship between serum vitamin D (25[OH]D3) and food allergy

Koplin, Jennifer J., Suaini, Noor H.A., Vuillermin, Peter, Ellis, Justine A., Panjari, Mary, Ponsonby, Anne-Louise, Peters, Rachel L., Matheson, Melanie C., Martino, David, Dang, Thanh, Osborne, Nicholas J., Martin, Pamela, Lowe, Adrian, Gurrin, Lyle C., Tang, Mimi L.K., Wake, Melissa, Dwyer, Terry, Hopper, John, Dharmage, Shyamali C. and Allen, Katrina J. 2016, Polymorphisms affecting vitamin D-binding protein modify the relationship between serum vitamin D (25[OH]D3) and food allergy, Journal of allergy and clinical immunology, vol. 137, no. 2, pp. 500-506.e4, doi: 10.1016/j.jaci.2015.05.051.

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Title Polymorphisms affecting vitamin D-binding protein modify the relationship between serum vitamin D (25[OH]D3) and food allergy
Formatted title Polymorphisms affecting vitamin D-binding protein modify the relationship between serum vitamin D (25[OH]D₃) and food allergy
Author(s) Koplin, Jennifer J.
Suaini, Noor H.A.
Vuillermin, Peter
Ellis, Justine A.
Panjari, Mary
Ponsonby, Anne-Louise
Peters, Rachel L.
Matheson, Melanie C.
Martino, David
Dang, Thanh
Osborne, Nicholas J.
Martin, Pamela
Lowe, Adrian
Gurrin, Lyle C.
Tang, Mimi L.K.
Wake, Melissa
Dwyer, Terry
Hopper, John
Dharmage, Shyamali C.
Allen, Katrina J.
Journal name Journal of allergy and clinical immunology
Volume number 137
Issue number 2
Start page 500
End page 506.e4
Total pages 11
Publisher Mosby
Place of publication Maryland Heights, Mo.
Publication date 2016-02
ISSN 0091-6749
1097-6825
Keyword(s) food hypersensitivity
vitamin D
food allergy
gene polymorphism
vitamin D binding protein
Summary BACKGROUND: There is evolving evidence that vitamin D insufficiency may contribute to food allergy, but findings vary between populations. Lower vitamin D-binding protein (DBP) levels increase the biological availability of serum vitamin D. Genetic polymorphisms explain almost 80% of the variation in binding protein levels. OBJECTIVE: We sought to investigate whether polymorphisms that lower the DBP could compensate for adverse effects of low serum vitamin D on food allergy risk. METHODS: From a population-based cohort study (n = 5276) we investigated the association between serum 25-hydroxyvitamin D3 (25[OH]D3) levels and food allergy at age 1 year (338 challenge-proven food-allergic and 269 control participants) and age 2 years (55 participants with persistent and 50 participants with resolved food allergy). 25(OH)D3 levels were measured using liquid chromatography-tandem mass spectrometry and adjusted for season of blood draw. Analyses were stratified by genotype at rs7041 as a proxy marker of DBP levels (low, the GT/TT genotype; high, the GG genotype). RESULTS: Low serum 25(OH)D3 level (≤50 nM/L) at age 1 years was associated with food allergy, particularly among infants with the GG genotype (odds ratio [OR], 6.0; 95% CI, 0.9-38.9) but not in those with GT/TT genotypes (OR, 0.7; 95% CI, 0.2-2.0; P interaction = .014). Maternal antenatal vitamin D supplementation was associated with less food allergy, particularly in infants with the GT/TT genotype (OR, 0.10; 95% CI, 0.03-0.41). Persistent vitamin D insufficiency increased the likelihood of persistent food allergy (OR, 12.6; 95% CI, 1.5-106.6), particularly in those with the GG genotype. CONCLUSIONS: Polymorphisms associated with lower DBP level attenuated the association between low serum 25(OH)D3 level and food allergy, consistent with greater vitamin D bioavailability in those with a lower DBP level. This increases the biological plausibility of a role for vitamin D in the development of food allergy.
Language eng
DOI 10.1016/j.jaci.2015.05.051
Field of Research 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-Cell Therapies)
1107 Immunology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, American Academy of Allergy, Asthma & Immunology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30081499

Document type: Journal Article
Collection: School of Medicine
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