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Changes in abdominal obesity and age-related macular degeneration: the atherosclerosis risk in communities study

Peeters, Anna, Magliano, Dianna J., Stevens, June, Duncan, Bruce B., Klein, Ronald and Wong, Tien Y. 2008, Changes in abdominal obesity and age-related macular degeneration: the atherosclerosis risk in communities study, Archives of ophthalmology, vol. 126, no. 11, pp. 1554-1560, doi: 10.1001/archopht.126.11.1554.

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Title Changes in abdominal obesity and age-related macular degeneration: the atherosclerosis risk in communities study
Author(s) Peeters, AnnaORCID iD for Peeters, Anna orcid.org/0000-0003-4340-9132
Magliano, Dianna J.
Stevens, June
Duncan, Bruce B.
Klein, Ronald
Wong, Tien Y.
Journal name Archives of ophthalmology
Volume number 126
Issue number 11
Start page 1554
End page 1560
Total pages 7
Publisher American Medical Association
Place of publication Chicago, Ill.
Publication date 2008-11
ISSN 1538-3601
1538-3601
Keyword(s) Abdominal Fat
Atherosclerosis
Body Mass Index
Body Weight
Female
Follow-Up Studies
Humans
Macular Degeneration
Male
Middle Aged
Obesity
Odds Ratio
Risk Factors
United States
Waist-Hip Ratio
Science & Technology
Life Sciences & Biomedicine
Ophthalmology
BODY-MASS INDEX
BEAVER DAM EYE
CARDIOVASCULAR-DISEASE
PHYSICAL-ACTIVITY
WEIGHT CHANGE
MACULOPATHY
MEN
HYPERTENSION
PATHOGENESIS
Summary OBJECTIVE: To examine the association between changes in waist-hip ratio (WHR), a measure of abdominal obesity, and age-related macular degeneration (AMD). METHODS: A total of 12 515 persons from a population-based cohort study, aged 45 to 64 years in 1987 to 1989, were followed up over 6 years. The percentage change in WHR during follow-up was ranked into sex-specific deciles; an increase in WHR was defined as the top 10% of change and a decrease in WHR as the bottom 10%. The association of increased or decreased WHR and presence of AMD at follow-up was determined using logistic regression adjusting for potential confounders. RESULTS: The average change in WHR was an increase of 2%, ranging from a decrease of 44% to an increase of 102%. A decrease in WHR of 3% or more was associated with 29% lower odds of any AMD (odds ratio = 0.71; 95% confidence interval, 0.52-0.97). This effect was most pronounced among obese participants at baseline, where a decrease in WHR was associated with 59% lower odds of AMD (odds ratio = 0.41; 95% confidence interval, 0.20-0.82). CONCLUSIONS: Middle-aged persons who had a 3% or greater reduction in WHR over time were less likely to have AMD, particularly among those who were initially obese.
Language eng
DOI 10.1001/archopht.126.11.1554
Field of Research 111799 Public Health and Health Services not elsewhere classified
1113 Ophthalmology And Optometry
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2008, American Medical Association
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30081593

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.