Openly accessible

Cohort Profile: The Barwon Infant Study

Vuillermin, Peter, Saffery, Richard, Allen, Katrina J, Carlin, John B, Tang, Mimi L K, Ranganathan, Sarath, Burgner, David, Dwyer, Terry, Collier, Fiona, Jachno, Kim, Sly, Peter, Symeonides, Christos, McCloskey, Kathleen, Molloy, John, Forrester, Michael and Ponsonby, Anne-Louise 2015, Cohort Profile: The Barwon Infant Study, International journal of epidemiology, vol. 44, no. 4, pp. 1148-1160, doi: 10.1093/ije/dyv026.

Attached Files
Name Description MIMEType Size Downloads

Title Cohort Profile: The Barwon Infant Study
Author(s) Vuillermin, PeterORCID iD for Vuillermin, Peter
Saffery, Richard
Allen, Katrina J
Carlin, John B
Tang, Mimi L K
Ranganathan, Sarath
Burgner, David
Dwyer, Terry
Collier, Fiona
Jachno, Kim
Sly, Peter
Symeonides, Christos
McCloskey, Kathleen
Molloy, John
Forrester, Michael
Ponsonby, Anne-Louise
Journal name International journal of epidemiology
Volume number 44
Issue number 4
Start page 1148
End page 1160
Total pages 13
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2015-08-01
ISSN 0300-5771
Summary The modern environment is associated with an increasing burden of non-communicable diseases (NCDs). Mounting evidence implicates environmental exposures, experienced early in life (including in utero), in the aetiology of many NCDs, though the cellular/molecular mechanism(s) underlying this elevated risk across the life course remain unclear. Epigenetic variation has emerged as a candidate mediator of such effects. The Barwon Infant Study (BIS) is a population-derived birth cohort study (n ¼ 1074 infants) with ante-natal recruitment, conducted in the south-east of Australia (Victoria). BIS has been designed to facilitate a detailed mechanistic investigation of development within an epidemiological framework. The broad objectives are to investigate the role of specific environmental factors, gut microbiota and epigenetic variation in early-life development, and subsequent immune, allergic, cardiovascular, respiratory and neurodevelopmental outcomes. Participants have been reviewed at birth and at 1, 6, 9 and 12 months, with 2-and 4-year reviews under way. Biological samples and measures include: maternal blood, faeces and urine during pregnancy; infant urine, faeces and blood at regular intervals during the first 4 years; lung function at 1 month and 4 years; cardiovascular assessment at 1 month and 4 years; skin-prick allergy testing and food challenge at 1 year; and neurodevelopmental assessment at 9 months, 2 and 4 years. Data access enquiries can be made at [] or via [].
Language eng
DOI 10.1093/ije/dyv026
Field of Research 0104 Statistics
1117 Public Health And Health Services
Socio Economic Objective 920501 Child Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Oxford University Press
Free to Read? Yes
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 45 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 441 Abstract Views, 4 File Downloads  -  Detailed Statistics
Created: Tue, 23 Feb 2016, 11:51:00 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact