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Cohort Profile: The Barwon Infant Study

Vuillermin, Peter, Saffery, Richard, Allen, Katrina J, Carlin, John B, Tang, Mimi L K, Ranganathan, Sarath, Burgner, David, Dwyer, Terry, Collier, Fiona, Jachno, Kim, Sly, Peter, Symeonides, Christos, McCloskey, Kathleen, Molloy, John, Forrester, Michael and Ponsonby, Anne-Louise 2015, Cohort Profile: The Barwon Infant Study, International journal of epidemiology, vol. 44, no. 4, pp. 1148-1160, doi: 10.1093/ije/dyv026.

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Title Cohort Profile: The Barwon Infant Study
Author(s) Vuillermin, Peter
Saffery, Richard
Allen, Katrina J
Carlin, John B
Tang, Mimi L K
Ranganathan, Sarath
Burgner, David
Dwyer, Terry
Collier, Fiona
Jachno, Kim
Sly, Peter
Symeonides, Christos
McCloskey, Kathleen
Molloy, John
Forrester, Michael
Ponsonby, Anne-Louise
Journal name International journal of epidemiology
Volume number 44
Issue number 4
Start page 1148
End page 1160
Total pages 13
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2015-08-01
ISSN 0300-5771
Summary The modern environment is associated with an increasing burden of non-communicable diseases (NCDs). Mounting evidence implicates environmental exposures, experienced early in life (including in utero), in the aetiology of many NCDs, though the cellular/molecular mechanism(s) underlying this elevated risk across the life course remain unclear. Epigenetic variation has emerged as a candidate mediator of such effects. The Barwon Infant Study (BIS) is a population-derived birth cohort study (n ¼ 1074 infants) with ante-natal recruitment, conducted in the south-east of Australia (Victoria). BIS has been designed to facilitate a detailed mechanistic investigation of development within an epidemiological framework. The broad objectives are to investigate the role of specific environmental factors, gut microbiota and epigenetic variation in early-life development, and subsequent immune, allergic, cardiovascular, respiratory and neurodevelopmental outcomes. Participants have been reviewed at birth and at 1, 6, 9 and 12 months, with 2-and 4-year reviews under way. Biological samples and measures include: maternal blood, faeces and urine during pregnancy; infant urine, faeces and blood at regular intervals during the first 4 years; lung function at 1 month and 4 years; cardiovascular assessment at 1 month and 4 years; skin-prick allergy testing and food challenge at 1 year; and neurodevelopmental assessment at 9 months, 2 and 4 years. Data access enquiries can be made at [www.barwoninfantstudy.org.au] or via [peter.vuillermin@deakin.edu.au].
Language eng
DOI 10.1093/ije/dyv026
Field of Research 0104 Statistics
1117 Public Health And Health Services
Socio Economic Objective 920501 Child Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Oxford University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30081601

Document type: Journal Article
Collection: School of Medicine
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