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Early recognition of ipilimumab-related autoimmune hypophysitis in patients with metastatic melanoma: case studies and recommendations for management

Tiu, Crescens, Pezaro, Carmel, Davis, Ian D., Grossmann, Mathis and Parente, Phillip 2015, Early recognition of ipilimumab-related autoimmune hypophysitis in patients with metastatic melanoma: case studies and recommendations for management, Asia-Pacific journal of clinical oncology, vol. 11, no. 2, pp. 190-194, doi: 10.1111/ajco.12348.

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Title Early recognition of ipilimumab-related autoimmune hypophysitis in patients with metastatic melanoma: case studies and recommendations for management
Author(s) Tiu, Crescens
Pezaro, Carmel
Davis, Ian D.
Grossmann, Mathis
Parente, Phillip
Journal name Asia-Pacific journal of clinical oncology
Volume number 11
Issue number 2
Start page 190
End page 194
Total pages 5
Publisher Wiley
Place of publication London, Eng.
Publication date 2015-06
ISSN 1743-7563
Keyword(s) CTLA-4
autoimmune hypophysitis
ipilimumab
melanoma
Antibodies, Monoclonal
Humans
Male
Middle Aged
Summary Ipilimumab is a human anti-CTLA-4 monoclonal antibody recently approved for the treatment of advanced melanoma. Stimulation of T-cell activity unmasks antitumor activity, but can cause immune-related adverse events. Autoimmune hypophysitis is of particular importance because its presentation can be subtle but life threatening. We present two cases where early recognition of ipilimumab-related autoimmune hypophysitis led to timely intervention and low subsequent morbidity, without compromise of antitumor effects. We provide recommendations for detection and management of this potentially life-threatening complication of ipilimumab.
Language eng
DOI 10.1111/ajco.12348
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
1112 Oncology And Carcinogenesis
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30081613

Document type: Journal Article
Collection: School of Medicine
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