Fertility after young-onset colorectal cancer: a study of subjects with Lynch syndrome

Stupart, D., Win, A. K., Winship, I. M. and Jenkins, M. 2015, Fertility after young-onset colorectal cancer: a study of subjects with Lynch syndrome, Colorectal Disease, vol. 17, no. 9, pp. 787-793, doi: 10.1111/codi.12940.

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Title Fertility after young-onset colorectal cancer: a study of subjects with Lynch syndrome
Author(s) Stupart, D.
Win, A. K.
Winship, I. M.
Jenkins, M.
Journal name Colorectal Disease
Volume number 17
Issue number 9
Start page 787
End page 793
Total pages 7
Publisher Wiley
Place of publication London, Eng.
Publication date 2015-09
ISSN 1463-1318
Keyword(s) Fertility
colorectal cancer
lynch syndrome
Science & Technology
Life Sciences & Biomedicine
Gastroenterology & Hepatology
Summary AIM: Infertility is a concern for young survivors of colorectal cancer (CRC), but this risk is not well quantified. Carriers of mismatch repair (MMR) mutations are a useful cohort for studying fertility after CRC as they commonly develop CRC when young, and unaffected family members provide demographically similar controls. The aim of this study was to determine the effect of CRC on fertility in a large cohort of MMR mutation carriers. METHOD: Mismatch repair mutation carriers identified from the Australasian Colorectal Cancer Family Registry were included. For each year of life within the fertile age range (15-49), the number of living individuals and the number of children born to them were determined. Individuals were grouped by whether or not they had had a diagnosis of CRC by that age. Age-specific and total fertility rates were calculated. RESULTS: We identified 1068 subjects (611 women and 457 men), of whom 467 were diagnosed with CRC. There were 1192 births during 18 674 person-years of follow-up to the women and 814 births during 14 013 person-years of follow-up to the men. The total fertility rate was decreased in women after a diagnosis of CRC compared with those who did not have CRC (1.3 vs 2.2; P = 0.0011), but age-specific fertility was only reduced in the 20-24-year age group. In men the total fertility rate was similar for both groups (2.0 vs 1.8; P = 0.27). CONCLUSION: Age-specific fertility was decreased in female CRC survivors with Lynch syndrome aged 20-24, but not in older women or in men.
Language eng
DOI 10.1111/codi.12940
Field of Research 1103 Clinical Sciences
111299 Oncology and Carcinogenesis not elsewhere classified
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30081619

Document type: Journal Article
Collection: School of Medicine
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