The magnitude of association between overweight and obesity and the risk of diabetes: a meta-analysis of prospective cohort studies

Abdullah, Asnawi, Peeters, Anna, de Courten, Maximilian and Stoelwinder, Johannes 2010, The magnitude of association between overweight and obesity and the risk of diabetes: a meta-analysis of prospective cohort studies, Diabetes research and clinical practice, vol. 89, no. 3, pp. 309-319, doi: 10.1016/j.diabres.2010.04.012.

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Title The magnitude of association between overweight and obesity and the risk of diabetes: a meta-analysis of prospective cohort studies
Author(s) Abdullah, Asnawi
Peeters, AnnaORCID iD for Peeters, Anna orcid.org/0000-0003-4340-9132
de Courten, Maximilian
Stoelwinder, Johannes
Journal name Diabetes research and clinical practice
Volume number 89
Issue number 3
Start page 309
End page 319
Total pages 11
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2010-09
ISSN 1872-8227
Keyword(s) Adolescent
Adult
Aged
Aged, 80 and over
Body Mass Index
Diabetes Mellitus, Type 2
Female
Humans
Male
Middle Aged
Obesity
Overweight
Prospective Studies
Young Adult
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
BMI
Meta-analysis
Type 2 diabetes
BODY-MASS INDEX
FAT DISTRIBUTION
WAIST CIRCUMFERENCE
WEIGHT CHANGE
FOLLOW-UP
MELLITUS
TYPE-2
WOMEN
SEX
HYPERTENSION
Summary The objectives of this meta-analysis were to examine the magnitude of the relative risk (RR) of developing type 2 diabetes for overweight and obese populations, compared to those with normal weight, and to determine causes of the variation in RR between various cohort studies. The magnitude of the RR was analyzed by combining 18 prospective cohort studies that matched defined criteria. The variance in RR between studies was explored. The overall RR of diabetes for obese persons compared to those with normal weight was 7.19, 95% CI: 5.74, 9.00 and for overweight was 2.99, 95% CI: 2.42, 3.72. The variation in RR among studies was explored and it was found that the effect of heterogeneity was highly related with sample size, method of assessment of body mass index (BMI) and method of ascertainment of type 2 diabetes. By combining only cohort studies with more than 400 cases of incident diabetes (>median), adjusted by at least three main confounding variables (age, family history of type 2 diabetes, physical activity), measured BMI, and diabetes determined by clinical diagnosis, the RR was 7.28, 95% CI: 6.47, 8.28 for obesity and 2.92, 95% CI: 2.57, 3.32 for overweight.
Language eng
DOI 10.1016/j.diabres.2010.04.012
Field of Research 111799 Public Health and Health Services not elsewhere classified
1103 Clinical Sciences
Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2010, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30081708

Document type: Journal Article
Collections: Faculty of Health
School of Health and Social Development
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