Muscle redox signalling pathways in exercise. Role of antioxidants

Mason, Shaun A., Morrison, Dale, McConell, Glenn K. and Wadley, Glenn D. 2016, Muscle redox signalling pathways in exercise. Role of antioxidants, Free radical biology & medicine, vol. 98, Special issue : Human Performance and Redox Signaling in Health and Disease, pp. 29-45, doi: 10.1016/j.freeradbiomed.2016.02.022.

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Title Muscle redox signalling pathways in exercise. Role of antioxidants
Author(s) Mason, Shaun A.ORCID iD for Mason, Shaun A. orcid.org/0000-0002-6138-2239
Morrison, Dale
McConell, Glenn K.
Wadley, Glenn D.ORCID iD for Wadley, Glenn D. orcid.org/0000-0002-6617-4359
Journal name Free radical biology & medicine
Volume number 98
Season Special issue : Human Performance and Redox Signaling in Health and Disease
Start page 29
End page 45
Total pages 17
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016
ISSN 0891-5849
1873-4596
Keyword(s) antioxidants
exercise
nitric oxide
reactive oxygen species
skeletal muscle
Summary Recent research highlights the importance of redox signalling pathway activation by contraction-induced reactive oxygen species (ROS) and nitric oxide (NO) in normal exercise-related cellular and molecular adaptations in skeletal muscle. In this review, we discuss some potentially important redox signalling pathways in skeletal muscle that are involved in acute and chronic responses to contraction and exercise. Specifically, we discuss redox signalling implicated in skeletal muscle contraction force, mitochondrial biogenesis and antioxidant enzyme induction, glucose uptake and muscle hypertrophy. Furthermore, we review evidence investigating the impact of major exogenous antioxidants on these acute and chronic responses to exercise. Redox signalling pathways involved in adaptive responses in skeletal muscle to exercise are not clearly elucidated at present, and further research is required to better define important signalling pathways involved. Evidence of beneficial or detrimental effects of specific antioxidant compounds on exercise adaptations in muscle is similarly limited, particularly in human subjects. Future research is required to not only investigate effects of specific antioxidant compounds on skeletal muscle exercise adaptations, but also to better establish mechanisms of action of specific antioxidants in vivo. Although we feel it remains somewhat premature to make clear recommendations in relation to application of specific antioxidant compounds in different exercise settings, a bulk of evidence suggests that N-acetylcysteine (NAC) is ergogenic through its effects on maintenance of muscle force production during sustained fatiguing events. Nevertheless, a current lack of evidence from studies using performance tests representative of athletic competition and a potential for adverse effects with high doses (>70 mg/kg body mass) warrants caution in its use for performance enhancement. In addition, evidence implicates high dose vitamin C (1 g/day) and E (≥260 IU/day) supplementation in impairments to some skeletal muscle cellular adaptations to chronic exercise training. Thus, determining the utility of antioxidant supplementation in athletes likely requires a consideration of training and competition periodization cycles of athletes in addition to type, dose and duration of antioxidant supplementation.
Language eng
DOI 10.1016/j.freeradbiomed.2016.02.022
Field of Research 110602 Exercise Physiology
110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30081817

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